Editing Antiplatelet drug (section)

==Drug toxicity==
Antiplatelet drugs effect may be affected by patient's medications, current medical conditions, food and supplements taken. Antiplatelet drugs effect may be increased or decreased. An increase in antiplatelet effect would increase the risk of bleeding and could cause prolonged or excessive bleeding. A decrease in antiplatelet effect would reduce the risk of bleeding, but increase the thromboembolic risk.<ref name=":0" /> Drug toxicity may increase when multiple antiplatelet drugs are used. Gastrointestinal bleeding is a common adverse event seen in many patients.<ref>{{cite journal | vauthors = Shehab N, Sperling LS, Kegler SR, Budnitz DS | title = National estimates of emergency department visits for hemorrhage-related adverse events from clopidogrel plus aspirin and from warfarin | journal = Archives of Internal Medicine | volume = 170 | issue = 21 | pages = 1926–1933 | date = November 2010 | pmid = 21098354 | doi = 10.1001/archinternmed.2010.407 | doi-access = free }}</ref>

=== Medications ===
Medications that may increase antiplatelet drug effect:<ref name=":0" />
* Cytotoxic drugs or drugs associated with bone marrow suppression (e.g.: leflunomide, hydroxychloroquine, adalimumab, infliximab, etanercept, sulfasalazine, penicillamine, gold, methotrexate, azathioprine, mycophenolate)
* Drugs affecting the nervous system (e.g.: [[Selective serotonin reuptake inhibitor]]s (SSRIs))
* NSAIDS (e.g.: aspirin, ibuprofen, diclofenac, naproxen)
* Other anticoagulants or antiplatelet drugs
Medications that may decrease antiplatelet drug effect:<ref name=":0" />
* Carbamazepine
* Erythromycin
* Fluconazole
* Omeprazole
Use of NSAIDs as part of dental management of patients with vascular disease should be discouraged as NSAIDs have antiplatelet effect. Instead, simple analgesics such as paracetamol or co-codamol should be of first choice. If NSAIDs are required, the risk of bleeding increases with duration of dental treatment.<ref name=":0" />

=== Medical conditions ===
Medical conditions that may increase antiplatelet drugs' effect include:<ref name=":0" />

Chronic [[kidney failure]], [[liver disease]], haematological malignancy, recent or current [[chemotherapy]], advanced heart failure, mild forms of inherited bleeding disorders (e.g. [[haemophilia]], [[Von Willebrand's disease]]) and [[idiopathic thrombocytopenic purpura]].

=== Food and supplements ===
Food and supplements that may increase antiplatelet drugs' effect:<ref name=":0" />

St. John's wort, ginkgo biloba, garlic.