Editing Anandamide (section)

== Transport ==

[[Endocannabinoid transporters]] for anandamide and [[2-arachidonoylglycerol]] include the [[heat shock protein]]s ([[Hsp70]]s) and [[Fatty acid-binding protein|fatty acid binding proteins]] (FABPs).<ref name = "pnasus2009">{{cite journal | vauthors = Kaczocha M, Glaser ST, Deutsch DG | title = Identification of intracellular carriers for the endocannabinoid anandamide | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 106 | issue = 15 | pages = 6375–6380 | date = April 2009 | pmid = 19307565 | pmc = 2669397 | doi = 10.1073/pnas.0901515106 | doi-access = free | bibcode = 2009PNAS..106.6375K }}</ref><ref name = "cb2009">{{cite journal | vauthors = Oddi S, Fezza F, Pasquariello N, D'Agostino A, Catanzaro G, De Simone C, Rapino C, Finazzi-Agrò A, Maccarrone M | title = Molecular identification of albumin and Hsp70 as cytosolic anandamide-binding proteins | journal = Chemistry & Biology | volume = 16 | issue = 6 | pages = 624–632 | date = June 2009 | pmid = 19481477 | doi = 10.1016/j.chembiol.2009.05.004 | doi-access = }}</ref>

Anandamide shows a preference for binding to [[cholesterol]] and [[ceramide]] over other membrane lipids. Cholesterol acts as a binding partner for anandamide. Initially, a [[hydrogen bond]] facilitates their interaction. Following this, anandamide is drawn towards the membrane interior, where it forms a molecular complex with cholesterol. This process involves a conformational adaptation of anandamide to the apolar membrane environment. Subsequently, the anandamide-cholesterol complex is directed to the cannabinoid receptor (CB1) and then exits.<ref>{{cite journal | vauthors = Di Scala C, Fantini J, Yahi N, Barrantes FJ, Chahinian H | title = Anandamide Revisited: How Cholesterol and Ceramides Control Receptor-Dependent and Receptor-Independent Signal Transmission Pathways of a Lipid Neurotransmitter | journal = Biomolecules | volume = 8 | issue = 2 | page = 31 | date = May 2018 | pmid = 29789479 | pmc = 6022874 | doi = 10.3390/biom8020031 | doi-access = free }}</ref>