Editing Adenosine diphosphate (section)

==Blood platelet activation==
Under normal conditions, small disk-shape [[platelet]]s circulate in the blood freely and without interaction with one another. ADP is stored in [[Platelet|dense bodies]] inside [[blood]] [[platelet]]s and is released upon platelet activation. ADP interacts with a family of ADP receptors found on platelets (P2Y1, [[P2Y12]], and P2X1), which leads to platelet activation.<ref>{{cite journal |vauthors =Murugappa S, Kunapuli SP |title=The role of ADP receptors in platelet function |journal=Front. Biosci. |volume=11 |pages=1977–86 |year=2006 |pmid=16368572|url=http://www.bioscience.org/2006/v11/af/1939/fulltext.htm |doi=10.2741/1939|doi-access=free }}</ref>
* '''P2Y1''' receptors initiate platelet aggregation and shape change as a result of interactions with ADP.
* '''P2Y12''' receptors further amplify the response to ADP and draw forth the completion of aggregation.
ADP in the blood is converted to [[adenosine]] by the action of [[ecto-ADPase]]s, inhibiting further platelet activation via [[adenosine receptor]]s.{{cn|date=April 2023}}