Editing 5α-Reductase 2 deficiency (section)

==Society and culture==

=== Dominican Republic ===
In the Dominican Republic, ''güevedoces'' are regarded as a [[third gender]] and experience ambivalent [[Socialization#Gender socialization|gender socialisation]].<ref name="AFS2">{{cite book |last1=Fausto-Sterling |first1=Anne |author-link=Anne Fausto-Sterling |title=Sexing the Body: Gender politics and the construction of sexuality |date=2000 |publisher=Basic Books |isbn=0465077145 |edition=1st |location=New York, NY |page=109}}</ref> In adulthood, they most commonly [[Gender identity|self-identify]] as men, but are not necessarily completely treated as such by society.<ref name="AFS" />

=== Papua New Guinea ===
In Papua New Guinea, it has been said that the "girl" is shunned when he begins his natural transformation into a male body and socially assumes a male gender role.<ref>{{cite journal |vauthors=Imperato-McGinley J, Miller M, Wilson JD, Peterson RE, Shackleton C, Gajdusek DC |date=April 1991 |title=A cluster of male pseudohermaphrodites with 5 alpha-reductase deficiency in Papua New Guinea |journal=Clin Endocrinol |volume=34 |issue=4 |pages=293–8 |doi=10.1111/j.1365-2265.1991.tb03769.x |pmid=1831738 |s2cid=84664559}}</ref>

===Sport===
In April 2014, the ''[[BMJ]]'' reported that four elite athletes with 5-ARD were subjected to sterilization and "partial [[Clitoridectomy|clitoridectomies]]" in order to compete in [[women's sport]]. The authors noted that "partial clitoridectomy" was "not medically indicated, does not relate to real or perceived athletic 'advantage,{{'"}} relating to elevated androgen levels. The athletes were all from developing countries where lifetime access to hormone replacement may prove elusive.<ref>{{cite journal |author=Rebecca Jordan-Young |author-link=Rebecca Jordan-Young |author2=Peter Sonksen |author3=Katrina Karkazis |author3-link=Katrina Karkazis|title= Sex, health, and athletes |journal=[[BMJ]]|volume=348|pages=g2926|year=2014 |doi=10.1136/bmj.g2926|url=http://www.bmj.com/content/348/bmj.g2926 |pmid=24776640|s2cid=2198650 }}</ref> Intersex advocates regard this intervention as "a clearly coercive process".<ref>{{cite web|url=https://ihra.org.au/27745/un-human-rights-council-side-event-the-time-has-come/|title=UN Human Rights Council: resolution, statement and side event, "The time has come"|publisher=[[Organisation Intersex International Australia]]|access-date=2 February 2021|date=2014-09-11}}</ref>

===Popular culture===
In the ''[[Nip/Tuck]]'' season three episode "Quentin Costa", it is revealed that [[Quentin Costa]] had 5-ARD.<ref>{{cite book |last1=Steinhoff |first1=H. |title=Transforming Bodies: Makeovers and Monstrosities in American Culture |date=26 May 2015 |publisher=Springer |isbn=978-1-137-49379-8 |url=https://books.google.com/books?id=7xANCgAAQBAJ&pg=PA184 |language=en}}</ref>

[[Jeffrey Eugenides]]' Pulitzer Prize-winning 2002 novel ''[[Middlesex (novel)|Middlesex]]'' is about a young man with 5-ARD. The character was originally born Calliope and raised as a girl, but upon realizing his genetic sex, he transitions into Cal.<ref>{{cite journal |last1=Hsu |first1=Stephanie |title=Ethnicity and the Biopolitics of Intersex in Jeffrey Eugenides's 'Middlesex' |journal=MELUS |date=2011 |volume=36 |issue=3 |pages=87–110 |doi=10.1353/mel.2011.0045 |jstor=23035264 |s2cid=146517414 }}</ref><ref>{{cite news |title=Jeffrey Eugenides's Middlesex gave me the courage to take risks in my writing {{!}} Nadifa Mohamed |url=https://www.theguardian.com/commentisfree/2014/aug/25/middlesex-jeffrey-eugenides-intersex-book-changed-me |access-date=26 December 2021 |work=the Guardian |date=25 August 2014 |language=en}}</ref>

===Notable people===
* [[Caster Semenya]]<ref>{{Cite news |first=Sean |last=Ingle |url=http://www.theguardian.com/sport/2019/jun/18/caster-semenya-iaaf-athletics-guinea-pig|title=Caster Semenya accuses IAAF of using her as a 'guinea pig experiment' |date=June 18, 2019 |newspaper=[[The Guardian]] }}</ref><ref>{{Cite news |first=Matteo |last=Winkler |url=https://papers.ssrn.com/sol3/papers.cfm?abstract_id=3805794|title=Of Athletes, Bodies and Rules: Making Sense of 'Caster Semenya' |date=18 Mar 2021 |newspaper=[[SSRN]] |ssrn=3805794 }}</ref>