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== Deaths == [[File:明武宗画像.jpg|thumb|110px|[[Zhengde Emperor]]]] [[File:Ferdinand Magellan.jpg|thumb|110px|[[Ferdinand Magellan]]]] [[File:Juan Ponce de Leon.jpg|thumb|110px|[[Juan Ponce de León]]]] [[File:Margaret of Lorraine.jpg|thumb|110px|Saint [[Margaret of Lorraine]]]] [[File:Raffael 042.jpg|thumb|110px|[[Pope Leo X]]]] [[File:Manuel I1.jpg|thumb|110px|King [[Manuel I of Portugal]]]] [[File:Domenico Spadafora.jpg|thumb|110px|Blessed [[Domenico Spadafora]]]] * [[January 6]] – Cardinal [[William de Croÿ (bishop)|William de Croÿ]] (b. [[1497]])<ref>{{cite book |last1=Fisquet |first1=Honoré |title=La France pontificale |date=1864 |publisher=Etienne Repos |page=229 |url=https://books.google.com/books?id=oql2vG7C91AC&dq=Guillaume+de+Cro%C3%BF+%226+janvier+1521%22&pg=PA229 |access-date=27 July 2023 |language=fr}}</ref> * [[January 15]] – [[John II, Duke of Cleves]] (b. [[1458]])<ref>{{cite web |title=Johann II. |url=https://www.deutsche-biographie.de/gnd119135574.html#ndbcontent |website=www.deutsche-biographie.de |access-date=27 July 2023 |language=de}}</ref> * [[April 20]] – [[Zhengde Emperor]] of China (b. [[1491]])<ref>{{cite book |title=中国官场总览 |date=1999 |publisher=經濟日報出版社 |page=1658 |url=https://books.google.com/books?id=BoF4AAAAIAAJ&q=%E6%AD%A3%E5%BE%B7%E7%9A%87%E5%B8%9D+%221521%E5%B9%B44%E6%9C%8820%E6%97%A5%22 |access-date=27 July 2023 |language=zh}}</ref> * [[April 24]] – Spanish rebels (executed)<ref name="REV" /> ** [[Juan López de Padilla]] ** [[Juan Bravo]] ** [[Francisco Maldonado]] * [[April 27]] – [[Ferdinand Magellan]], Portuguese explorer (b. [[1480]])<ref>{{cite book|author1=Deborah Wei|author2=Rachael Kamel|title=Resistance in Paradise: Rethinking 100 Years of U.S. Involvement in the Caribbean and the Pacific|url=https://books.google.com/books?id=i6F6AAAAMAAJ|year=1998|publisher=American Friends Service Committee|isbn=978-0-910082-33-4|page=15}}</ref> * [[April 28]] – [[Suzanne, Duchess of Bourbon]] (b. [[1491]])<ref>{{cite book |last1=La-Mure |first1=Jean Marie de |title=Histoire des ducs de Bourbon et des comtes de Forez: en forme d'annales sur preuves authentiques |date=1868 |publisher=Potier |page=564 |url=https://books.google.com/books?id=G2OE0vOGV9YC&dq=Suzanne+de+Bourbon+%2228+avril+1521%22&pg=PA564 |access-date=27 July 2023 |language=fr}}</ref> * [[May 10]] – [[Sebastian Brant]], German humanist and satirist (b. [[1457]])<ref>{{cite book|author1=Max Reinhart|author2=James N. Hardin|title=German Writers of the Renaissance and Reformation, 1280-1580|url=https://books.google.com/books?id=qcwUAQAAIAAJ|year=1997|publisher=Gale Research|isbn=978-0-7876-1069-2|page=21}}</ref> * [[May 17]] – [[Edward Stafford, 3rd Duke of Buckingham]] (executed) (b. [[1478]])<ref name="ES" /> * [[June 15]] – [[Tamás Bakócz]], Hungarian Catholic cardinal and statesman (b. [[1442]])<ref>{{cite book |last1=Herbermann |first1=Charles George |title=The Catholic Encyclopedia |date=1913 |volume=2|publisher=Encyclopedia Press |page=214 |url=https://books.google.com/books?id=LwIjAQAAIAAJ&dq=Tam%C3%A1s+Bak%C3%B3cz+%2215+june+1521%22&pg=PA214 |access-date=27 July 2023 |language=en}}</ref> * [[June 22]] – [[Leonardo Loredan]], Doge of Venice (b. [[1436]])<ref>{{cite book |last1=Cappelletti |first1=Giuseppe |title=Storia della repubblica di Venezia dal suo principio sino al giorno d'oggi |date=1852 |volume=8,9|publisher=G. Antenelli |page=33 |url=https://books.google.com/books?id=LlJKAAAAYAAJ&dq=Leonardo+Loredan+%2222+giugno+1521%22&pg=PA33 |access-date=27 July 2023 |language=it}}</ref> * July – [[Juan Ponce de León]], Spanish conquistador (b. [[1460]])<ref>{{cite book |last1=Slavicek |first1=Louise Chipley |title=Juan Ponce de León |date=2009 |publisher=Infobase Publishing |isbn=978-1-4381-0684-7 |page=87 |url=https://books.google.com/books?id=qNUPY1CGZ1MC&dq=Juan+Ponce+de+Le%C3%B3n+%22july+1521%22&pg=PA87 |access-date=27 July 2023 |language=en}}</ref> * [[July 9]] – [[Raffaele Riario]], Italian cardinal (b. [[1461]])<ref>{{cite web |title=The Cardinals of the Holy Roman Church - Biographical Dictionary - Consistory of December 10, 1477 |url=https://cardinals.fiu.edu/bios1477.htm#Sansoni |website=cardinals.fiu.edu |access-date=27 July 2023}}</ref> * [[August 27]] – [[Josquin des Prez]], Flemish composer (b. c. [[1450]])<ref>{{cite book |last1=Elders |first1=Willem |title=Josquin Des Prez and His Musical Legacy: An Introductory Guide |date=2013 |publisher=Leuven University Press |isbn=978-90-5867-941-3 |page=17 |url=https://books.google.com/books?id=dZNMAQAAQBAJ&dq=Josquin+des+Prez+%2227+august+1521%22&pg=PA17 |access-date=27 July 2023 |language=en}}</ref> * [[September 12]] – In the [[Italian War of 1521–1526|Italian War]], the Holy Roman Empire abandons its siege of the French-controlled city of [[Parma]] after 17 days.<ref>{{cite book |last1=Mallett |first1=Michael |last2=Shaw |first2=Christine |title=The Italian Wars: 1494–1559 |date=2012 |publisher=Pearson Education Limited |location=Harlow |page=141 |isbn=978-0-582-05758-6}}</ref> * [[September 15]] – **[[Gazi Husrev Bey]] replaces Bali-beg Jahjapašić as the [[Sanjak of Bosnia|Ottoman Governor of Bosnia]]. **[[Teodosie of Wallachia|Teodosie]] becomes the new [[List of princes of Wallachia|Voivode of Wallachia]], at the capital, [[Târgoviște|Targoviste]], now in [[Romania]]. * [[October 7]] – [[Margaret of Anhalt-Köthen]], Princess of Anhalt by birth, Duchess consort of Saxony (b. [[1494]])<ref>{{cite book |last1=Kohnle |first1=Armin |last2=Rudersdorf |first2=Manfred |title=Briefe und Akten zur Kirchenpolitik Friedrichs des Weisen und Johanns...: Band 2: 1518–1522. Bearbeitet von Stefan Michel, Beate Kusche, Ulrike Ludwig, Konstantin Enge, Dagmar Blaha und Alexander Bartmuß unter Mitarbeit von Saskia Jähnigen und Steven Bickel |date=28 June 2022 |publisher=Evangelische Verlagsanstalt |isbn=978-3-374-07173-9 |page=20 |url=https://books.google.com/books?id=3zpxEAAAQBAJ&dq=Margarete+von+Anhalt+%227+oktober+1521%22&pg=PA20 |access-date=27 July 2023 |language=de}}</ref> * [[October 22]] – [[Edward Poynings]], Lord Deputy to King [[Henry VII of England]] (b. [[1459]])<ref>{{cite ODNB |title=Poynings, Sir Edward|url=https://www.oxforddnb.com/display/10.1093/ref:odnb/9780198614128.001.0001/odnb-9780198614128-e-22683|year=2004 |access-date=27 July 2023 |language=en |doi=10.1093/ref:odnb/22683}}</ref> * [[October 24]] – [[Robert Fayrfax]], English Renaissance composer (b. [[1464]])<ref>{{cite book |last1=Fayrfax |first1=Robert |title=Sacred Music from the Lambeth Choirbook |date=1 January 1985 |publisher=A-R Editions, Inc. |isbn=978-0-89579-150-4 |page=viii |url=https://books.google.com/books?id=-StRhNWLgtUC&dq=Robert+Fayrfax+%2224+october+1521%22&pg=PR8 |access-date=27 July 2023 |language=en}}</ref> * [[November 2]] – [[Margaret of Lorraine]], French Duchess of Alençon, [[Roman Catholic]] nun and blessed (b. [[1463]])<ref>{{cite book |last1=Laurent |first1=Eugène |title=Histoire de Marguerite de Lorraine, Duchesse d'Alençon, bisaïeule de Henri IV., etc |date=1854 |publisher=Barbier |page=306 |url=https://books.google.com/books?id=SN9ZAAAAcAAJ&q=%222%20novembre%201521%22 |access-date=27 July 2023 |language=fr}}</ref> * [[December 1]] – [[Pope Leo X]] (b. [[1475]])<ref>{{cite web |title=Leo X {{!}} pope |url=https://www.britannica.com/biography/Leo-X |website=Encyclopedia Britannica |access-date=1 December 2020 |language=en}}</ref> * [[December 13]] – King [[Manuel I of Portugal]] (b. [[1469]])<ref>{{cite book |last1=Costa |first1=António Leite da |title=História de Portugal |date=4 November 2019 |publisher=Leya |isbn=978-972-20-6863-5 |page=109 |url=https://books.google.com/books?id=QOC_DwAAQBAJ&dq=Manuel+I+de+Portugal+%2213+de+dezembro+de+1521%22&pg=PA109 |access-date=27 July 2023 |language=pt-PT}}</ref> * [[December 21]] – [[Domenico Spadafora]], Italian [[Roman Catholic]] priest and blessed (b. [[1450]])<ref>{{cite book |last1=Brigliadori |first1=Egidio |last2=Pasquini |first2=Agostino |title=Religiosità in Valconca: vicende e figure |date=2000 |publisher=Silvana |isbn=978-88-8215-266-6 |page=122 |url=https://books.google.com/books?id=4sYRAQAAIAAJ&q=%20%2221%20dicembre%201521%22 |access-date=27 July 2023 |language=it}}</ref> <gallery widths="154px" heights="200px" perrow="5" caption="1521 in art"> File:Ferdinand Magellan.jpg|March–April: [[Ferdinand Magellan]]'s voyage around the world. File:Martin Luther.jpg|[[May 25]]: [[Martin Luther]] outlawed. File:Hans Maler, Kunsthistorisches Museum Wien, Gemäldegalerie - Bildnis eines bartlosen Mannes - GG 884 - Kunsthistorisches Museum.jpg|[[Hans Maler zu Schwaz]], ''Portrait of a beardless man'' with the inscription:<br>"ALS MAN. 1521. ZALT. WAS. ICH. 33. IAR ALT"<br>([[mutatis mutandis]] to English: "as we had in 1521, I was 33 years old) File:Lorenzo Lotto - Christ Taking Leave of his Mother - WGA13674.jpg|[[Lorenzo Lotto]], ''Christ Taking Leave of His Mother'' </gallery>
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