Editing Vancomycin (section)

====Ototoxicity====<!-- This section is linked from Vancomycin (this page)-->
Attempts to establish rates of vancomycin-induced [[ototoxicity]] are even more difficult due to lack of good data. The consensus is that clearly related cases of vancomycin ototoxicity are rare.<ref name="pmid31693679">{{cite journal |vauthors=Humphrey C, Veve MP, Walker B, Shorman MA |title=Long-term vancomycin use had low risk of ototoxicity |journal=PLOS ONE |volume=14 |issue=11 |pages=e0224561 |date=2019 |pmid=31693679 |pmc=6834250 |doi=10.1371/journal.pone.0224561 |bibcode=2019PLoSO..1424561H |doi-access=free }}</ref><ref name="pmid33767665">{{cite journal |vauthors=Rybak LP, Ramkumar V, Mukherjea D |title=Ototoxicity of Non-aminoglycoside Antibiotics |journal=Front Neurol |volume=12 |pages=652674 |date=2021 |pmid=33767665 |pmc=7985331 |doi=10.3389/fneur.2021.652674 |url= |doi-access=free }}</ref> The association between vancomycin serum levels and ototoxicity is also uncertain. Cases of ototoxicity have been reported in patients whose vancomycin serum level exceeded 80&nbsp;μg/mL,<ref name="pmid12225605">{{cite journal |vauthors=Launay-Vacher V, Izzedine H, Mercadal L, Deray G |title=Clinical review: use of vancomycin in haemodialysis patients |journal=Crit Care |volume=6 |issue=4 |pages=313–6 |date=August 2002 |pmid=12225605 |pmc=137311 |doi=10.1186/cc1516 |url= |doi-access=free }}</ref> but cases have also been reported in patients with therapeutic levels. Thus it remains unknown whether [[therapeutic drug monitoring]] of vancomycin for the purpose of maintaining "therapeutic" levels prevents ototoxicity.<ref name="pmid12225605"/> Still, therapeutic drug monitoring can be used during vancomycin therapy to minimize the risk of ototoxicity associated with excessive drug exposure.<ref name="pmid38304144"/>