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=== Notable vaccine investigations === [[Dengvaxia]], the only approved vaccine for [[Dengue fever]], was found to increase the risk of hospitalization for Dengue fever by 1.58 times in children of 9 years or younger, resulting in the suspension of a mass vaccination program in the Philippines in 2017.<ref>{{cite journal | vauthors = Redoni M, Yacoub S, Rivino L, Giacobbe DR, Luzzati R, Di Bella S | title = Dengue: Status of current and under-development vaccines | journal = Reviews in Medical Virology | volume = 30 | issue = 4 | pages = e2101 | date = July 2020 | pmid = 32101634 | doi = 10.1002/rmv.2101 | hdl-access = free | s2cid = 211536962 | hdl = 1983/6d38d9b6-8e1b-4a84-85e3-edab4fc41957 | url = https://research-information.bris.ac.uk/en/publications/6d38d9b6-8e1b-4a84-85e3-edab4fc41957 | access-date = 23 September 2021 | archive-date = 20 March 2022 | archive-url = https://web.archive.org/web/20220320141819/https://research-information.bris.ac.uk/en/publications/dengue-status-of-current-and-under-development-vaccines | url-status = live }}</ref> [[Pandemrix]] {{ndash}} a vaccine for the [[2009 swine flu pandemic vaccine|H1N1]] pandemic of 2009 given to around 31 million people<ref name="Chen-1998" /> {{ndash}} was found to have a higher level of adverse events than alternative vaccines resulting in legal action.<ref>{{cite journal | title = Pandemrix vaccine: why was the public not told of early warning signs? | journal = BMJ | volume = 362 | pages = k3948 | date = 20 September 2018 | pmid = 30237282 | doi = 10.1136/bmj.k3948 | s2cid = 52308748 | last1 = Doshi | first1 = Peter }}</ref> In a response to the [[narcolepsy]] reports following immunization with Pandemrix, the CDC carried out a population-based study and found the FDA-approved 2009 H1N1 flu shots were not associated with an increased risk for the neurological disorder.<ref>{{Cite web|url=https://www.cdc.gov/vaccinesafety/concerns/history/narcolepsy-flu.html|title=Narcolepsy Following Pandemrix in Europe|date=20 August 2020|website=U.S. [[Centers for Disease Control and Prevention]] (CDC)|access-date=3 January 2021|archive-date=27 June 2016|archive-url=https://web.archive.org/web/20160627180432/http://www.cdc.gov/vaccinesafety/concerns/history/narcolepsy-flu.html|url-status=live}}</ref>
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