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==Economy== {{More citations needed|date=January 2009}} [[File:Sees Candies headquarters.jpg|thumb|Headquarters of [[See's Candies]] on El Camino Real, South San Francisco]] South San Francisco does not levy [[Gross receipts tax|gross receipts]] or [[Payroll tax|payroll]] taxes, although companies have to pay a business fee of up to $125,000 per year.<ref name=":2">{{Cite web|url=https://www.sfchronicle.com/business/article/2nd-most-valuable-U-S-startup-to-leave-SF-as-14558067.php|title=2nd most valuable U.S. startup to leave SF as city loses another headquarters|last=Li|first=Roland|date=October 24, 2019|website=[[San Francisco Chronicle]]|language=en-US|access-date=March 17, 2020}}</ref> According to city representatives, who emphasize a business-friendly image in line with "The Industrial City" hill sign, it instead relies on mostly on revenue from property, sales and hotel taxes.<ref name=":2" /> Much of what is now South San Francisco was initially agricultural land, and was originally known as Baden. Small pockets of farmland still exist near [[San Bruno Mountain]], but these lands have, over the years, been replaced by residential subdivisions. Acres of Orchids, founded by the Rod McLellan Company in the late 1920s, was one such example of a farm being converted to housing. Once one of the largest facilities in the United States producing [[orchids]] and [[gardenia]]s, the nursery closed in 1998.<ref>{{Cite web|url=https://www.mercurynews.com/2021/03/06/shooting-in-oaklands-adam-point-area-leaves-man-dead/|title=Peninsula news | The Mercury News and Palo Alto Daily News|website=The Mercury News|date=March 6, 2021}}</ref> A new housing tract now sits upon the land formerly occupied by Acres of Orchids greenhouses, off El Camino near Hickey. [[File:South San Francisco gateway sign.jpg|thumb|right|A sign placed at the entrance to the Biotech Area declares South San Francisco to be the "Birthplace of Biotechnology."]] The flat land east of Bayshore Freeway (US 101) is the R&D Campus of South San Francisco. South San Francisco is home to [[Genentech]], one of the world's largest biotech companies, as well as a satellite office of [[Amgen]], the world's largest biotech firm. Many other biotech companies, such as [[Exelixis]], have also started or moved to South San Francisco to be in proximity to [[University of California, San Francisco|UCSF]], [[Stanford University]], and [[University of California, Berkeley|UC Berkeley]]; all are within an hour's drive. A sign located on East Grand Avenue declares South San Francisco as the "Birthplace of Biotechnology."<ref>{{Full citation needed|date=June 2015}}Perrigan, Dana.[http://www.sfgate.com/cgi-bin/object/article?f=/c/a/2009/02/15/REJK15QBMH.DTL&o=1 "Proud of past, South San Francisco looks ahead"],"The San Francisco Chronicle", February 15, 2009, accessed July 26, 2011.</ref> The headquarters and main factory of [[See's Candies]] is located in South San Francisco, having moved from the original plant in Los Angeles due to the cooler weather.<ref>"[http://www.sees.com/index.cfm/about_us About Us]." ''See's Candies''. Retrieved on January 18, 2009.</ref> [[Galoob]] had its headquarters in South San Francisco before [[Hasbro]] bought the company in 1998.<ref>Fost, Dan. "[https://www.sfgate.com/business/article/Hasbro-Adds-Galoob-to-Its-Toy-Chest-2988518.php Hasbro Adds Galoob to Its Toy Chest]." ''[[San Francisco Chronicle]]''. Tuesday September 29, 1998. Retrieved on April 25, 2010.</ref> [[Air China]] operates an office in South San Francisco.<ref>"[http://www.airchina.com.cn/AboutAirChina/ContactUs/InternationalOffice/default.shtml International Offices] {{webarchive|url=https://web.archive.org/web/20081217150646/http://www.airchina.com.cn/AboutAirChina/ContactUs/InternationalOffice/default.shtml |date=December 17, 2008 }}." ''[[Air China]]''. Retrieved on January 18, 2009.</ref> Hudson Soft USA (a subsidiary of [[Hudson Soft]], and [[Sanrio|Sanrio, Inc.]]) had its headquarters in South San Francisco.<ref>"[http://nl.newsbank.com/nl-search/we/Archives?p_product=SJ&s_site=mercurynews&p_multi=SJ&p_theme=realcities&p_action=search&p_maxdocs=200&p_topdoc=1&p_text_direct-0=0EB71A76CE11FF2D&p_field_direct-0=document_id&p_perpage=10&p_sort=YMD_date:D&s_trackval=GooglePM KIDS' GIFTS: A NINTENDO NIGHTMARE BAD-BOY VIDEO GAMES HAVE PARENTS, MAKERS TALKING MODERATION]." ''[[San Jose Mercury News]]''. December 20, 1992. 1A Front. Retrieved on July 12, 2010. "Hudson Soft USA Inc. of South San Francisco..."</ref> In October 2019, online payment processing company [[Stripe (company)|Stripe]] became South San Francisco's largest tenant by signing a lease for {{convert|421,000|ft2|m2}} of office space in the redeveloped [[Oyster Point Marina/Park|Oyster Point]], announcing it would be moving its headquarters there from neighboring San Francisco in 2021.<ref name=":2" /> ===Top employers=== The city's top employers - according to the city's 2022 Annual Comprehensive Financial Report,<ref name="cafr">{{cite web |url=https://www.ssf.net/home/showpublisheddocument/29105/638120532036470000 |title=South San Francisco ACFR 2022 |website=www.ssf.net |access-date=October 28, 2023}}</ref>), California Employment Development Department,<ref>{{cite web|url=https://labormarketinfo.edd.ca.gov/majorer/countymajorer.asp?CountyCode=000081 |title=Major Employers in San Mateo County |website=www.labormarketinfo.edd.ca.gov/ |access-date=March 15, 2025}}</ref> and the National Center for Education Statistics<ref>{{citeweb|url=https://nces.ed.gov/ccd/districtsearch/district_detail.asp?Search=1&DistrictID=0637530&DistrictType=1&DistrictType=2&DistrictType=3&DistrictType=4&DistrictType=5&DistrictType=6&DistrictType=7&DistrictType=8&DistrictType=9&NumOfStudentsRange=more&NumOfSchoolsRange=more&ID2=0637530&details=2 |title=South San Francisco Unified District Directory Information (2023-2024 School Year) |website=wwww.nces.ed.gov |access-date=March 15, 2025}}</ref> include: {| class="wikitable" |- ! # ! Employer ! # of Employees |- | 1 |[[Genentech]] |8,632 |- | 2 |[[Kaiser Permanente]] - South San Francisco |1,000 - 4,999 |- | 3 |[[AbbVie]] |1,000 |- | 4 |[[South San Francisco Unified School District]] | 857 |- | 5 |[[Costco Wholesale]] | 834 |- | 6 |[[Life Technologies (Thermo Fisher Scientific)|Life Technologies Corporation]] | 622 |- | 7 |[[Amgen]] | 600 |- | 8 |[[Verily Life Sciences]] | 555 |- | 9 |City of South San Francisco |more than 500<ref>{{cite web|url=https://www.linkedin.com/company/cityofsouthsanfrancisco/about/ |title=Overview:City of South San Francisco |website=www.linkedin.com/company/cityofsouthsanfrancisco/ |access-date=March 15, 2025}}</ref> |- |10 |[[Amazon.com]] Services, Inc | 425 |- |11 |[[ZS Associates]], Inc. | 390 |- |12 |MRL San Francisco LLC | 317 |- |13 |Frank & Grossman Landscape Contractors | 265 |} Other significant employers located in SSF include [[FedEx]], Health Plan of San Mateo, Mercedes-Benz of San Francisco, [[Safeway]], [[SamTrans]], [[United Parcel Service]]. There are more than thirty hotels with over 2,700 rooms combined, plus more than forty event spaces.
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