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Sodium dodecyl sulfate
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====Miscellaneous applications==== SLS is used in an improved technique for preparing brain tissues for study by optical microscopy. The technique, which has been branded as CLARITY, was the work of Karl Deisseroth and coworkers at [[Stanford University]], and involves infusion of the organ with an [[acrylamide]] solution to bind the macromolecules of the organ ([[protein]]s, [[nucleic acid]]s, etc.), followed by thermal polymerization to form a "brain–hydrogel" (a mesh interspersed throughout the tissue to fix the macromolecules and other structures in space), and then by lipid removal using SDS to eliminate [[light scattering]] with minimal protein loss, rendering the tissue quasi-transparent.<ref name=ShenNatureNews2013>{{cite journal | last=Shen | first = Helen | year = 2013 | title=See-through brains clarify connections | journal = Nature | volume = 496 | issue = 7444; April 10 | page = 151 | doi = 10.1038/496151a | pmid = 23579658 | bibcode = 2013Natur.496..151S | doi-access = free }}{{better source|date=March 2016}}</ref><ref name=ChungDeisserothNature2013>{{cite journal |author = Chung, K. |author2=Wallace, J. |author3=Kim, S.-Y. |author4=Kalyanasundaram, S. |author5=Andalman, A.S. |author6=Davidson, T.J. |author7=Mirzabekov, J.J. |author8=Zalocusky, K.A. |author9= Mattis, J. |author10=Denisin, A.K. |author11=Pak, Sally |author12=Bernstein, H. |author13=Ramakrishnan, C. |author14=Grosenick, L. |author15=Gradinaru, V. |author16=Deisseroth, K. |display-authors=3 | year = 2013 | title= Structural and molecular interrogation of intact biological systems | journal = Nature | volume = 497 | issue = 7449; May 16 | pages = 332–37 | doi = 10.1038/nature12107 | quote = Obtaining high-resolution information from a complex system, while maintaining the global perspective needed to understand system function, represents a key challenge in biology. Here we address this challenge with a method (termed CLARITY) for the transformation of intact tissue into a nanoporous hydrogel-hybridized form (crosslinked to a three-dimensional network of hydrophilic polymers) that is fully assembled but optically transparent and macromolecule-permeable. | pmid=23575631 | pmc=4092167|bibcode=2013Natur.497..332C }}</ref> Along with [[sodium dodecylbenzene sulfonate]] and [[Triton X-100]], aqueous solutions of SDS are popular for dispersing or suspending nanotubes, such as [[carbon nanotube]]s.<ref>{{cite journal|last1=Islam|first1=M. F.| year = 2003 | title=High Weight Fraction Surfactant Solubilization of Single-Wall Carbon Nanotubes in Water|journal=Nano Letters|volume=3|issue=2|pages=269–73|doi=10.1021/nl025924u|bibcode=2003NanoL...3..269I}}</ref>
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