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==Medicinal smoking== {{one source|section|date=October 2023}} Throughout recorded history, humans have used the smoke of [[medicinal plant]]s to cure illness. A sculpture from [[Persepolis]] shows [[Darius the Great]] (522β486 BC), the king of [[Persia]], with two [[censer]]s in front of him for burning [[Peganum harmala]] and/or [[sandalwood]] [[Santalum album]], which was believed to protect the king from evil and disease. More than 300 plant species in 5 continents are used in smoke form for different diseases. As a method of [[drug administration]], smoking is important as it is a simple, inexpensive, but very effective method of extracting particles containing active agents. More importantly, generating smoke reduces the particle size to a microscopic scale thereby increasing the absorption of its active chemical principles.<ref>{{cite journal |doi=10.1016/j.jep.2006.09.005 |title=Medicinal smokes |year=2006 |last1=Mohagheghzadeh |first1=Abdolali |last2=Faridi |first2=Pouya |last3=Shams-Ardakani |first3=Mohammadreza |last4=Ghasemi |first4=Younes |journal=Journal of Ethnopharmacology |volume=108 |issue=2 |pages=161β84 |pmid=17030480}}</ref>
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