Editing Sertraline (section)

===Other anxiety disorders===
Sertraline has been successfully used for the treatment of [[social anxiety disorder]].<ref>{{cite journal | vauthors = Hansen RA, Gaynes BN, Gartlehner G, Moore CG, Tiwari R, Lohr KN | title = Efficacy and tolerability of second-generation antidepressants in social anxiety disorder | journal = International Clinical Psychopharmacology | volume = 23 | issue = 3 | pages = 170–9 | date = May 2008 | pmid = 18408531 | pmc = 2657552 | doi = 10.1097/YIC.0b013e3282f4224a }}</ref><ref name="pmid17092192">{{cite journal | vauthors = Davidson JR | title = Pharmacotherapy of social anxiety disorder: what does the evidence tell us? | journal = The Journal of Clinical Psychiatry | volume = 67 | issue = Suppl 12 | pages = 20–6 | year = 2006 | pmid = 17092192 | doi=10.1016/j.genhosppsych.2005.07.002}}</ref> All three major domains of the disorder (fear, avoidance, and physiological symptoms) respond to sertraline.<ref name="pmid21456103" /> Maintenance treatment, after the response is achieved, prevents the return of the symptoms.<ref name="pmid18374843">{{cite journal |vauthors=Stein MB, Stein DJ |title=Social anxiety disorder |journal=Lancet |volume=371 |issue=9618 |pages=1115–25 |date=March 2008 |pmid=18374843 |doi=10.1016/S0140-6736(08)60488-2 |s2cid=29814976 |hdl=10983/15923 |hdl-access=free }}</ref> The improvement is greater among the patients with later, adult onset of the disorder.<ref name="pmid17963189">{{cite journal |vauthors=Herpertz SC, Zanarini M, Schulz CS, Siever L, Lieb K, Möller HJ |title=World Federation of Societies of Biological Psychiatry (WFSBP) guidelines for biological treatment of personality disorders |journal=World J Biol Psychiatry |volume=8 |issue=4 |pages=212–44 |date=2007 |pmid=17963189 |doi=10.1080/15622970701685224 |s2cid=14077861 }}</ref> In a comparison trial, sertraline was superior to [[exposure therapy]], but patients treated with the psychological intervention continued to improve during a year-long follow-up, while those treated with sertraline deteriorated after treatment termination.<ref name="pmid16318597">{{cite journal |vauthors=Hollon SD, Stewart MO, Strunk D |title=Enduring effects for cognitive behavior therapy in the treatment of depression and anxiety |journal=Annu Rev Psychol |volume=57 |pages=285–315 |date=2006 |pmid=16318597 |doi=10.1146/annurev.psych.57.102904.190044 }}</ref> The combination of sertraline and [[cognitive behavioral therapy]] appears to be more effective in children and young people than either treatment alone.<ref name="pmid23834458">{{cite journal |vauthors=Mandrioli R, Mercolini L, Raggi MA |title=Evaluation of the pharmacokinetics, safety and clinical efficacy of sertraline used to treat social anxiety |journal=Expert Opin Drug Metab Toxicol |volume=9 |issue=11 |pages=1495–505 |date=November 2013 |pmid=23834458 |doi=10.1517/17425255.2013.816675 |s2cid=658089 |url=}}</ref>

Sertraline has not been approved for the treatment of [[generalized anxiety disorder]]; however, several guidelines recommend it as a first-line medication referring to good quality controlled clinical trials.<ref name="nice-gad">{{cite web |url=https://www.nice.org.uk/guidance/cg113/resources/generalised-anxiety-disorder-and-panic-disorder-in-adults-management-pdf-35109387756997 |title=www.nice.org.uk }}</ref><ref name="pmid12516310"/><ref name="pmid25081580"/>