Editing Radiation therapy (section)

===Effects on pituitary system===
[[Hypopituitarism]] commonly develops after radiation therapy for sellar and parasellar neoplasms, extrasellar brain tumors, head and neck tumors, and following whole body irradiation for systemic malignancies.<ref name=Fernandez_2009/> 40–50% of children treated for childhood cancer develop some endocrine side effect.<ref>{{cite journal |last1=Sklar |first1=CA |last2=Antal |first2=Z |last3=Chemaitilly |first3=W |last4=Cohen |first4=LE |last5=Follin |first5=C |last6=Meacham |first6=LR |last7=Murad |first7=MH |title=Hypothalamic-Pituitary and Growth Disorders in Survivors of Childhood Cancer: An Endocrine Society Clinical Practice Guideline. |journal=The Journal of Clinical Endocrinology and Metabolism |date=1 August 2018 |volume=103 |issue=8 |pages=2761–2784 |doi=10.1210/jc.2018-01175 |pmid=29982476|s2cid=51601915 |doi-access=free }}</ref> Radiation-induced hypopituitarism mainly affects [[growth hormone]] and [[gonadal hormone]]s.<ref name="Fernandez_2009">{{cite journal | vauthors = Fernandez A, Brada M, Zabuliene L, Karavitaki N, Wass JA | title = Radiation-induced hypopituitarism | journal = Endocrine-Related Cancer | volume = 16 | issue = 3 | pages = 733–772 | date = September 2009 | pmid = 19498038 | doi = 10.1677/ERC-08-0231 | doi-access = free }}</ref> In contrast, [[adrenocorticotrophic hormone]] (ACTH) and [[thyroid stimulating hormone]] (TSH) deficiencies are the least common among people with radiation-induced hypopituitarism.<ref name=Fernandez_2009/> Changes in [[prolactin]]-secretion is usually mild, and vasopressin deficiency appears to be very rare as a consequence of radiation.<ref name=Fernandez_2009/>