Editing Pseudomonadota (section)

=== Human health ===
Studies have suggested Pseudomonadota as a relevant signature of disease in the human [[Gastrointestinal tract|gastrointestinal]] (GI) tract, by operating as a marker for microbiota instability.<ref name="Rizzatti_2017" /> The human gut [[microbiome]] consists mainly of four phyla: [[Firmicutes]], [[Bacteroidetes]], [[Actinobacteria]], and Pseudomonadota.<ref name="Rizzatti_2017" /> Microorganism gut colonization is dynamic from birth to death, with stabilization at the first few years of life, to higher diversity in adults, to reduced diversity in the elderly.<ref name="Rizzatti_2017" /> The gut microbiome conducts processes like nutrient synthesis, chemical [[metabolism]], and the formation of the gut barrier.<ref name="Rizzatti_2017" /> Additionally, the gut microbiome facilitates host interactions with its surrounding environment through regulation of nutrient absorption and bacterial intake. In 16s rRNA and [[Metagenomics|metagenome]] sequencing studies, Proteobacteria have been identified as bacteria that prompts [[endotoxemia]] (an inflammatory gut response) and metabolic disorders in human GI tracts.<ref name="Rizzatti_2017" /> Another study by Michail et al. showed a correlation of microbial composition in children with and without [[nonalcoholic fatty liver disease]] (NAFLD), wherein patients with NAFLD have a higher abundance of [[Gammaproteobacteria]] than patients without the disease.<ref>{{cite journal | vauthors = Michail S, Lin M, Frey MR, Fanter R, Paliy O, Hilbush B, Reo NV | title = Altered gut microbial energy and metabolism in children with non-alcoholic fatty liver disease | journal = FEMS Microbiology Ecology | volume = 91 | issue = 2 | pages = 1–9 | date = February 2015 | pmid = 25764541 | pmc = 4358749 | doi = 10.1093/femsec/fiu002 | doi-access = free}}</ref>

Classes Betaproteobacteria and Gammaproteobacteria are prevalent within the human oral cavity, and are markers for good oral health.<ref name="Leão_2023" /> The oral microbiome consists of 11 habitats, including the tongue dorsum, [[hard palate]], tonsils, throat, saliva, and more.<ref name="Jia_2018">{{cite journal | vauthors = Jia G, Zhi A, Lai PF, Wang G, Xia Y, Xiong Z, Zhang H, Che N, Ai L | title = The oral microbiota - a mechanistic role for systemic diseases | journal = British Dental Journal | volume = 224 | issue = 6 | pages = 447–455 | date = March 2018 | pmid = 29569607 | doi = 10.1038/sj.bdj.2018.217 | doi-access = free}}</ref> Changes in the oral microbiome are due to [[Endogeny (biology)|endogenous]] and [[Exogeny|exogenous]] factors like host lifestyle, [[genotype]], environment, immune system, and [[Socioeconomic status|socioeconomic]] status.<ref name="Jia_2018" /> Considering diet as a factor, high [[saturated fatty acid]] (SAF) content, achieved through poor diet, has been correlated to increased abundance of Betaproteobacteria in the oral cavity.<ref name="Jia_2018" />