Editing Proteomics (section)

===Distinct proteins are made under distinct settings===
A cell may make different sets of proteins at different times or under different conditions, for example during [[developmental biology|development]], [[cellular differentiation]], [[cell cycle]], or [[carcinogenesis]]. Further increasing proteome complexity, as mentioned, most proteins are able to undergo a wide range of post-translational modifications.

Therefore, a "proteomics" study may become complex very quickly, even if the topic of study is restricted. In more ambitious settings, such as when a [[#Biomarkers|biomarker]] for a specific cancer subtype is sought, the proteomics scientist might elect to study multiple blood serum samples from multiple cancer patients to minimise confounding factors and account for experimental noise.<ref>{{cite journal | vauthors = Srinivas PR, Verma M, Zhao Y, Srivastava S | title = Proteomics for cancer biomarker discovery | journal = Clinical Chemistry | volume = 48 | issue = 8 | pages = 1160–1169 | date = August 2002 | pmid = 12142368 }}</ref> Thus, complicated experimental designs are sometimes necessary to account for the dynamic complexity of the proteome.