Editing Prostaglandin (section)

==== Other terminal prostaglandin synthases ====
Terminal prostaglandin syntheses have been identified that are responsible for the formation of other prostaglandins. For example, hematopoietic and [[lipocalin]] [[prostaglandin D synthase]]s (hPGDS and lPGDS) are responsible for the formation of [[PGD2|PGD<sub>2</sub>]] from PGH<sub>2</sub>. Similarly, prostacyclin (PGI<sub>2</sub>) synthase (PGIS) converts PGH<sub>2</sub> into PGI<sub>2</sub>. A thromboxane synthase ([[thromboxane-A synthase|TxAS]]) has also been identified.
[[Prostaglandin-F synthase]] (PGFS) catalyzes the formation of 9α,11β-PGF<sub>2α,β</sub> from PGD<sub>2</sub> and PGF<sub>2α</sub> from PGH<sub>2</sub> in the presence of NADPH. This enzyme has recently been crystallized in complex with PGD<sub>2</sub><ref>{{cite journal | vauthors = Komoto J, Yamada T, Watanabe K, Takusagawa F | title = Crystal structure of human prostaglandin F synthase (AKR1C3) | journal = Biochemistry | volume = 43 | issue = 8 | pages = 2188–98 | date = March 2004 | pmid = 14979715 | doi = 10.1021/bi036046x }}</ref> and bimatoprost<ref>{{cite journal | vauthors = Komoto J, Yamada T, Watanabe K, Woodward DF, Takusagawa F | title = Prostaglandin F2alpha formation from prostaglandin H2 by prostaglandin F synthase (PGFS): crystal structure of PGFS containing bimatoprost | journal = Biochemistry | volume = 45 | issue = 7 | pages = 1987–96 | date = February 2006 | pmid = 16475787 | doi = 10.1021/bi051861t }}</ref> (a synthetic analogue of PGF<sub>2α</sub>).