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===''Cycle of Life and Death''=== [[File:Poison Ivy Pamela Isley.png|thumb|175px|Poison Ivy as Dr. Pamela Isley, PhD in ''Poison Ivy: Cycle of Life and Death'' #1 (March 2016). Art by Clay Mann and Seth Mann.]] In January 2016, DC Comics debuted Ivy's first solo comic book series, ''[[Poison Ivy: Cycle of Life and Death]]''. The series begins with Ivy attempting to go straight by returning to her science career. Under her human identity of Dr. Pamela Isley, she joins the plant sciences department at the famed Gotham Botanical Gardens, but things quickly get complicated when Luisa Cruz, Ivy's friend and mentor, is murdered via poisoning. Ivy investigates the murder whilst completing a genetic engineering research project begun by Cruz that culminates in the creation of two plant-human hybrid children known as Rose and Hazel. With the help of Selina Kyle and fellow researcher Darshan, Poison Ivy finds that the Gotham Botanical Gardens are performing experiments, using Ivy's research, which result in the creation of another plant-human hybrid child known as Thorn. Ivy destroys the laboratory and rescues the child. Ivy raises Rose, Hazel and Thorn who grow to adult size at an exponential rate, becoming young women within 35 weeks. When the girls sneak out to see Gotham City at night for the first time, they cause an incident at a strip club that gets the police involved, and Ivy has to help them escape. Returning to the apartment, Ivy locks Rose, Hazel and Thorn away so they will not leave again. Ivy finds Doctor Eric Grimley, Chair of the Gotham Botanical Gardens Research Department, waiting for her. Grimley had been conducting experiments with Ivy's research to cure his own cancer; he had then murdered Luisa because she was suspicious of the experiments he was performing. Now, with his cancer returning, he intends to harvest Rose, Thorn, and Hazel for spores to be used as another cure. He attacks Ivy, and transforms into a giant, plant-like monster. Darshan arrives and releases the girls. Ivy, Rose, Hazel, Thorn, and Darshan, along with [[Alec Holland (comics)|Swamp Thing]] (who seeks to kill Grimley for trying to break the cycle of life and death) fight and defeat Grimley, with Thorn hacking him up with a machete. Darshan later helps Rose, Thorn, and Hazel leave Ivy, reasoning that they were getting so restless they would go eventually with or without his help. They set off away from Gotham to places unknown, saying they plan to live out their lives regardless of how short they may be.
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