Editing Piperidine (section)

==List of piperidine medications==
[[File:Minoxidil structure.svg|class=skin-invert-image|thumb|right|160px|[[Minoxidil]] is a piperidine derivative widely used to prevent hair loss.]]
Piperidine and its derivatives are ubiquitous building blocks in pharmaceuticals<ref>{{cite journal|author1=Vitaku, E. |author2=D. T. Smith |author3=J. T. Njardarson |year=2014|title=Analysis of the Structural Diversity, Substitution Patterns, and Frequency of Nitrogen Heterocycles among U.S. FDA Approved Pharmaceuticals|journal=Journal of Medicinal Chemistry |volume=57|issue=24|pages=10257–10274|doi=10.1021/jm501100b|pmid=25255204}}</ref> and fine chemicals. The piperidine structure is found in, for example:
* [[Icaridin]] (Insect repellent)
*SSRIs ([[selective serotonin reuptake inhibitors]])
**[[Paroxetine]]
*[[Stimulants]] and [[nootropic]]s:
**[[Methylphenidate]]
**[[Ethylphenidate]]
**[[Pipradrol]]
**[[Desoxypipradrol]]
*Histamine 1 (H<sub>1</sub>) receptor antagonists/inverse agonists:
**[[Loratadine]]
* [[Histamine H3 receptor|Histamine 3 (H<sub>3</sub>) receptor]] antagonists/[[inverse agonist]]s:
**[[Pitolisant]]
*SERM ([[selective estrogen receptor modulators]])
**[[Raloxifene]]
*[[Vasodilator]]s
**[[Minoxidil]]
*[[Antipsychotic]] medications:
**[[Droperidol]]
**[[Haloperidol]]
**[[Melperone]]
**[[Mesoridazine]]
**[[Risperidone]]
**[[Thioridazine]]
*[[Opioid]]s:
**[[Dipipanone]]
**[[Fentanyl]] and analogs
**[[Loperamide]]
**[[Pethidine]] (meperidine)
**[[Prodine]]
*[[Arylcyclohexylamine]]s:
**[[Phencyclidine|PCP]] and analogs
*[[anticholinergic]] [[chemical weapons]]
**[[Ditran]]
**[[N-methyl-3-piperidyl benzilate|''N''-Methyl-3-piperidyl benzilate]] (JB-336, BZ)
Piperidine is also commonly used in chemical degradation reactions, such as the sequencing of [[DNA]] in the cleavage of particular modified [[nucleotides]]. Piperidine is also commonly used as a base for the [[Protecting group|deprotection]] of [[Fmoc]]-[[amino acid]]s used in solid-phase [[peptide synthesis]].

Piperidine is listed as a Table II precursor under the [[United Nations Convention Against Illicit Traffic in Narcotic Drugs and Psychotropic Substances]] due to its use (peaking in the 1970s) in the clandestine manufacture of [[phencyclidine]].<ref>{{cite web|url=http://www.incb.org/pdf/e/list/red.pdf |title=List of Precursors and Chemicals Frequently Used in the Illicit Manufacture of Narcotic Drugs and Psychotropic Substances Under International Control |publisher=International Narcotics Control Board |url-status=dead |archive-url=https://web.archive.org/web/20080227224025/http://www.incb.org/pdf/e/list/red.pdf |archive-date=2008-02-27 }}</ref>