Editing Pediatrics (section)

=== Elimination ===
Drug elimination is primarily facilitated via the liver and kidneys.<ref name=":1" /> In infants and young children, the larger relative size of their kidneys leads to increased [[renal]] clearance of medications that are eliminated through urine.<ref name=":2" /> In [[Preterm birth|preterm]] neonates and infants, their kidneys are slower to mature and thus are unable to clear as much drug as fully developed kidneys. This can cause unwanted drug build-up, which is why it is important to consider lower doses and greater dosing intervals for this population.<ref name=":0" /><ref name=":1" /> Diseases that negatively affect kidney function can also have the same effect and thus warrant similar considerations.<ref name=":1" />