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====Weightlessness and radiation==== {{Main|Weightlessness|Radiobiology}} [[Human evolution|Humans evolved]] for life in Earth [[Gravitation|gravity]], and exposure to weightlessness has been shown to have deleterious effects on human health. Initially, more than 50% of astronauts experience [[space motion sickness]]. This can cause nausea and vomiting, [[Vertigo (medical)|vertigo]], headaches, [[lethargy]], and overall malaise. The duration of space sickness varies, but it typically lasts for 1β3 days, after which the body adjusts to the new environment. Longer-term exposure to weightlessness results in [[muscle atrophy]] and deterioration of the skeleton, or [[spaceflight osteopenia]]. These effects can be minimized through a regimen of exercise.{{sfn|Kanas|Manzey|2008|pp=15β48}} Other effects include fluid redistribution, slowing of the [[cardiovascular system]], decreased production of [[red blood cell]]s, balance disorders, and a weakening of the [[immune system]]. Lesser symptoms include loss of body mass, nasal congestion, sleep disturbance, and puffiness of the face.<ref name=cmaj180_13_1317/> During long-duration space travel, radiation can pose an [[acute health hazard]]. Exposure to high-energy, ionizing [[cosmic rays]] can result in fatigue, nausea, vomiting, as well as damage to the immune system and changes to the [[white blood cell]] count. Over longer durations, symptoms include an increased risk of cancer, plus damage to the eyes, [[nervous system]], lungs and the [[Human gastrointestinal tract|gastrointestinal tract]].<ref name=nsbri_radiation/> On a round-trip [[Mars]] mission lasting three years, a large fraction of the cells in an astronaut's body would be traversed and potentially damaged by high energy nuclei.<ref name=curtis_and_Letaw/> The energy of such particles is significantly diminished by the shielding provided by the walls of a spacecraft and can be further diminished by water containers and other barriers. The impact of the cosmic rays upon the shielding produces additional radiation that can affect the crew. Further research is needed to assess the radiation hazards and determine suitable countermeasures.<ref name=sas4_11_1013/>
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