Editing Morphogenesis (section)

===Branching morphogenesis===
{{Further|Lung#Development|Breast development}}
In the development of the [[lung]] a bronchus branches into bronchioles forming the [[respiratory tree]].<ref name="Wolpert">{{cite book|last1=Wolpert|first1=Lewis|title=Principles of development|date=2015|publisher=Oxford University Press|isbn=978-0-19-967814-3|pages=499–500|edition=5th}}</ref> The branching is a result of the tip of each bronchiolar tube bifurcating, and the process of branching morphogenesis forms the bronchi, bronchioles, and ultimately the alveoli.<ref name="Miura">{{Cite book|last1=Miura|first1=T|title=Multiscale Modeling of Developmental Systems|date=2008|volume=81|pages=291–310|doi=10.1016/S0070-2153(07)81010-6|pmid=18023732|series=Current Topics in Developmental Biology|isbn=9780123742537|chapter=Modeling Lung Branching Morphogenesis}}</ref>

Branching morphogenesis is also evident in the [[Mammary duct|ductal formation]] of the [[mammary gland]].<ref>{{cite journal |vauthors=Fata JE, Werb Z, Bissell MJ |title=Regulation of mammary gland branching morphogenesis by the extracellular matrix and its remodeling enzymes |journal=Breast Cancer Res. |volume=6 |issue=1 |pages=1–11 |year=2004 |pmid=14680479 |pmc=314442 |doi=10.1186/bcr634 |doi-access=free }}</ref><ref name="Sternlicht">{{cite journal |author=Sternlicht MD |title=Key stages in mammary gland development: the cues that regulate ductal branching morphogenesis |journal=Breast Cancer Res. |volume=8 |issue=1 |pages=201 |year=2006 |pmid=16524451 |pmc=1413974 |doi=10.1186/bcr1368 |doi-access=free }}</ref> Primitive duct formation begins in [[prenatal development|development]], but the branching formation of the duct system begins later in response to [[estrogen]] during puberty and is further refined in line with mammary gland development.<ref name="Sternlicht"/><ref name="HynesWatson2010">{{cite journal|last1=Hynes|first1=N. E.|last2=Watson|first2=C. J.|title=Mammary Gland Growth Factors: Roles in Normal Development and in Cancer|journal=Cold Spring Harbor Perspectives in Biology|volume=2|issue=8|year=2010|pages=a003186|issn=1943-0264|doi=10.1101/cshperspect.a003186|pmid=20554705|pmc=2908768}}</ref><ref name="HarrisLippman2012">{{cite book|author1=Jay R. Harris|author2=Marc E. Lippman|author3=C. Kent Osborne|author4=Monica Morrow|title=Diseases of the Breast|url=https://books.google.com/books?id=GLc8xYe239kC&pg=PT94|date=28 March 2012|publisher=Lippincott Williams & Wilkins|isbn=978-1-4511-4870-1|pages=94–}}</ref>