Editing Menarche (section)

====Conditions and disease states====
Studies have been conducted to observe the association of the timing of menarche with various conditions and diseases. Some studies have shown that there may be an association between early or late-age menarche and [[cardiovascular disease]], although the mechanism of the association is not well understood.<ref>{{cite journal | vauthors = Luijken J, van der Schouw YT, Mensink D, Onland-Moret NC | title = Association between age at menarche and cardiovascular disease: A systematic review on risk and potential mechanisms | journal = Maturitas | volume = 104 | pages = 96–116 | date = October 2017 | pmid = 28923182 | doi = 10.1016/j.maturitas.2017.07.009 }}</ref> A systematic review has concluded that early onset of menarche is a risk factor for [[insulin resistance]]<ref>{{cite journal | vauthors = Zhang Z, Hu X, Yang C, Chen X | title = Early age at menarche is associated with insulin resistance: a systemic review and meta-analysis | journal = Postgraduate Medicine | volume = 131 | issue = 2 | pages = 144–50 | date = March 2019 | pmid = 30560708 | doi = 10.1080/00325481.2019.1559429 | s2cid = 56178701 }}</ref> and [[breast cancer]] risk.<ref>{{cite journal | vauthors = Kapil U, Bhadoria AS, Sareen N, Singh P, Dwivedi SN | title = Reproductive factors and risk of breast cancer: A Review | journal = Indian Journal of Cancer | volume = 51 | issue = 4 | pages = 571–76 | date = 2014 | pmid = 26842199 | doi = 10.4103/0019-509X.175345 | doi-access = free }}</ref>

There is conflicting evidence regarding the association between [[obesity]] and timing of menarche; a meta-analysis and systematic review has determined that more studies must be conducted to make any definitive conclusions about this association.<ref>{{cite journal | vauthors = Li W, Liu Q, Deng X, Chen Y, Liu S, Story M | title = Association between Obesity and Puberty Timing: A Systematic Review and Meta-Analysis | journal = International Journal of Environmental Research and Public Health | volume = 14 | issue = 10 | pages = 1266 | date = October 2017 | pmid = 29064384 | pmc = 5664767 | doi = 10.3390/ijerph14101266 | doi-access = free }}</ref>