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===Capsule=== [[File:Gray598.png|thumb|right|Lymph node tissue showing trabeculae]] Thin [[reticular fiber]]s (reticulin) of [[reticular connective tissue]] form a supporting meshwork inside the node.<ref name="Grays2016" /> These reticular cells also form a conduit network within the lymph node that functions as a molecular sieve, to prevent pathogens that enter the lymph node through afferent vessels re-enter the blood stream.<ref>{{cite journal |last1=Roozendaal |first1=Ramon |title=The conduit system of the lymph node |journal=International Immunology |date=September 29, 2008 |volume=20 |issue=12 |pages=1483β1487 |doi=10.1093/intimm/dxn110 |pmid=18824503 |url=https://pubmed.ncbi.nlm.nih.gov/18824503/ |access-date=22 November 2024}}</ref> The lymph node capsule is composed of [[dense irregular connective tissue]] with some plain [[collagen|collagenous fibers]], and a number of membranous processes or trabeculae extend from its internal surface. The trabeculae pass inward, radiating toward the center of the node, for about one-third or one-fourth of the space between the circumference and the center of the node. In some animals they are sufficiently well-marked to divide the peripheral or cortical portion of the node into a number of compartments (nodules), but in humans this arrangement is not obvious. The larger trabeculae springing from the capsule break up into finer bands, and these interlace to form a mesh-work in the central or medullary portion of the node. These trabecular spaces formed by the interlacing trabeculae contain the proper lymph node substance or lymphoid tissue. The node pulp does not, however, completely fill the spaces, but leaves between its outer margin and the enclosing trabeculae a channel or space of uniform width throughout. This is termed the subcapsular sinus (lymph path or lymph sinus). Running across it are a number of finer trabeculae of reticular fibers, mostly covered by ramifying cells.
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