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=== Interactions === ==== Alcohol ==== Drinking [[alcohol (drug)|alcohol]] when taking ibuprofen may increase the risk of [[stomach bleeding]].<ref name="drugs">{{cite web|url=https://www.drugs.com/ibuprofen.html|title=Ibuprofen|publisher=Drugs.com|url-status=live|archive-url=https://web.archive.org/web/20110806064653/http://www.drugs.com/ibuprofen.html|archive-date=6 August 2011}}</ref> ==== Aspirin ==== According to the FDA, "ibuprofen can interfere with the [[antiplatelet]] effect of low-dose [[aspirin]], potentially rendering aspirin less effective when used for [[cardioprotection]] and [[stroke]] prevention". Allowing sufficient time between doses of ibuprofen and immediate-release (IR) aspirin can avoid this problem. The recommended elapsed time between a dose of ibuprofen and a dose of aspirin depends on which is taken first. It would be 30 minutes or more for ibuprofen taken after IR aspirin, and 8 hours or more for ibuprofen taken before IR aspirin. However, this timing cannot be recommended for [[Enteric coating|enteric-coated]] aspirin. If ibuprofen is taken only occasionally without the recommended timing, though, the reduction of the cardioprotection and stroke prevention of a daily aspirin regimen is minimal.<ref name='FDA2006'>{{cite web |url=https://www.fda.gov/Drugs/DrugSafety/PostmarketDrugSafetyInformationforPatientsandProviders/ucm125222.htm |title=Information for Healthcare Professionals: Concomitant Use of Ibuprofen and Aspirin |access-date=22 November 2010 |date=September 2006 |publisher=U.S. [[Food and Drug Administration]] (FDA) |url-status=dead |archive-url=https://web.archive.org/web/20101113035657/https://www.fda.gov/Drugs/DrugSafety/PostmarketDrugSafetyInformationforPatientsandProviders/ucm125222.htm |archive-date=13 November 2010 }} *{{lay source |template= cite web|url = https://www.fda.gov/drugs/postmarket-drug-safety-information-patients-and-providers/information-about-taking-ibuprofen-and-aspirin-together|title = Information about Taking Ibuprofen and Aspirin Together|date = 9 September 2019 |website = U.S. [[Food and Drug Administration]] (FDA) }}</ref> ==== Paracetamol (acetaminophen) ==== Ibuprofen combined with [[paracetamol]] is considered generally safe in children for short-term usage.<ref>{{cite journal | vauthors = Kanabar DJ | title = A clinical and safety review of paracetamol and ibuprofen in children | journal = Inflammopharmacology | volume = 25 | issue = 1 | pages = 1β9 | date = February 2017 | pmid = 28063133 | pmc = 5306275 | doi = 10.1007/s10787-016-0302-3 }}</ref>
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