Editing Hyperglycemia (section)

====Insulin resistance====
Obesity has been contributing to increased [[insulin resistance]] in the global population. Insulin resistance increases hyperglycemia because the body becomes over saturated by glucose. Insulin resistance desensitizes insulin receptors, preventing insulin from lowering blood sugar levels.<ref>{{cite journal |date=2019 |title=Adipose Tissue Insulin Resistance in Youth on the Spectrum From Normal Weight to Obese and From Normal Glucose Tolerance to Impaired Glucose Tolerance to Type 2 Diabetes |journal=Diabetes Care |volume=42 |issue=2 |pages=265–272 |last1=Kim |first1=J. Y. |last2=Bacha |first2=F. |last3=Tfayli |first3=H. |last4=Michaliszyn |first4=S. F. |last5=Yousuf |first5=S. |last6=Arslanian |first6=S. |pmid=30455334 |doi=10.2337/dc18-1178 |pmc=6341282}}</ref>

The leading cause of hyperglycemia in [[type 2 diabetes]] is the failure of insulin to suppress glucose production by [[glycolysis]] and [[gluconeogenesis]] due to insulin resistance.<ref name="pmid30370538">{{cite journal |vauthors=Swe MT, Pongchaidecha A, Chatsudthipong V, Chattipakorn N, Lungkaphin A |title=Molecular signaling mechanisms of renal gluconeogenesis in nondiabetic and diabetic conditions |journal=[[Journal of Cellular Physiology]] |volume=234 |issue=6 |pages=8134–8151 |year=2019 |pmid=30370538 |doi=10.1002/jcp.27598 |s2cid=53097552}}</ref> Insulin normally inhibits glycogenolysis, but fails to do so in a condition of insulin resistance, resulting in increased glucose production.<ref name="pmid31377934">{{cite journal |vauthors=Sargsyan A, Herman MA |title=Regulation of Glucose Production in the Pathogenesis of Type 2 Diabetes |journal=[[Current Diabetes Reports]] |volume=19 |issue=9 |pages=77 |year=2019 |pmid=31377934 |doi=10.1007/s11892-019-1195-5 |pmc=6834297}}</ref> In the liver, [[FOXO6]] normally promotes gluconeogenesis in the fasted state, but insulin blocks Fox06 upon feeding.<ref name="pmid28213398">{{cite journal |vauthors=Lee S, Dong HH |title=FoxO integration of insulin signaling with glucose and lipid metabolism |journal=[[Journal of Endocrinology]] |volume=233 |issue=2 |pages=R67–R79 |year=2017 |pmid=28213398 |doi=10.1530/JOE-17-0002 |pmc=5480241}}</ref> In a condition of insulin resistance insulin fails to block Fox06, resulting in continued gluconeogenesis even upon feeding.<ref name="pmid28213398"/>