Editing Hydroxyproline (section)

==Clinical significance==
[[Proline]] hydroxylation requires [[ascorbic acid]] ([[vitamin C]]). The most obvious, first effects (gingival and hair problems) of absence of [[ascorbic acid]] in humans come from the resulting defect in [[hydroxylation]] of [[proline]] residues of [[collagen]], with reduced [[chemical stability|stability]] of the collagen molecule, causing [[scurvy]].

Increased serum and urine levels of hydroxyproline have also been demonstrated in [[Paget's disease of bone|Paget's disease]].<ref>{{cite web|url=http://www.wheelessonline.com/ortho/pagets_disease|title=Wheeless' Textbook of Orthopaedics|website=Wheeless Online|date=22 July 2020}}</ref>

[[Mass spectrometry]] analysis showed decreased amount of hydroxyproline [[post-translational modifications]] in non inflamed tissue from [[ulcerative colitis]] patients when compared to tissue from donors without the disease. <ref>{{cite web|url=https://pubs.rsc.org/en/content/articlelanding/2019/mo/c8mo00239h|title=Degradation of the extracellular matrix is part of the pathology of ulcerative colitis}}</ref>