Editing Glutathione (section)

===Metabolism===
Among the many metabolic processes in which it participates, glutathione is required for the biosynthesis of [[leukotriene]]s and [[prostaglandin]]s. It plays a role in the storage of cysteine. Glutathione enhances the function of [[citrulline]] as part of the [[nitric oxide]] cycle.<ref>{{cite journal | vauthors = Ha SB, Smith AP, Howden R, Dietrich WM, Bugg S, O'Connell MJ, Goldsbrough PB, Cobbett CS | title = Phytochelatin synthase genes from Arabidopsis and the yeast ''Schizosaccharomyces pombe'' | journal = The Plant Cell | volume = 11 | issue = 6 | pages = 1153–64 | date = June 1999 | pmid = 10368185 | pmc = 144235 | doi = 10.1105/tpc.11.6.1153 | jstor = 3870806 }}</ref> It is a [[cofactor (biochemistry)|cofactor]] and acts on [[glutathione peroxidase]].<ref name="Grant_2001">{{cite journal | vauthors = Grant CM | title = Role of the glutathione/glutaredoxin and thioredoxin systems in yeast growth and response to stress conditions | journal = Molecular Microbiology | volume = 39 | issue = 3 | pages = 533–541 | year = 2001 | pmid = 11169096 | doi = 10.1046/j.1365-2958.2001.02283.x | s2cid = 6467802 | doi-access = free }}</ref> Glutathione is used to produce S-sulfanylglutathione, which is part of [[hydrogen sulfide]] metabolism.<ref>{{cite journal |last1=Melideo |first1=SL |last2=Jackson |first2=MR |last3=Jorns |first3=MS |title=Biosynthesis of a central intermediate in hydrogen sulfide metabolism by a novel human sulfurtransferase and its yeast ortholog. |journal=Biochemistry |date=22 July 2014 |volume=53 |issue=28 |pages=4739–53 |doi=10.1021/bi500650h |pmid=24981631|pmc=4108183 }}</ref>