Editing Fibronectin (section)

== Fibronectin genetic variation as a protective factor against Alzheimer's disease ==
A specific genetic variation in Fibronectin gene was shown to reduce the risk of developing Alzheimer's disease in a multicenter, multiethnic genetic epidemiology and functional genomics study. This effect is believed to be through enhancing the brain's ability to clear the toxic waste and protein accumulation through the blood–brain barrier.<ref name="pmid38598053">{{cite journal | vauthors = Bhattarai P, Gunasekaran TI, Belloy ME, Reyes-Dumeyer D, Jülich D, Tayran H, Yilmaz E, Flaherty D, Turgutalp B, Sukumar G, Alba C, McGrath EM, Hupalo DN, Bacikova D, Le Guen Y, Lantigua R, Medrano M, Rivera D, Recio P, Nuriel T, Ertekin-Taner N, Teich AF, Dickson DW, Holley S, Greicius M, Dalgard CL, Zody M, Mayeux R, Kizil C, Vardarajan BN | title = Rare genetic variation in fibronectin 1 (FN1) protects against APOEε4 in Alzheimer's disease | journal = Acta Neuropathologica | volume = 147 | issue = 1 | pages = 70 | date = Apr 2024 | doi = 10.1007/s00401-024-02721-1 | pmid = 38598053| doi-access = free | pmc = 11006751 }}</ref>