Editing Effects of cannabis (section)

===Related to cannabinoids===
[[THC]], the principal [[psychoactive constituent]] of the cannabis plant, has an extremely low [[toxicity]] and the amount that can enter the body through the consumption of cannabis plants poses no threat of death. In dogs, the minimum lethal dose of THC is over 3000&nbsp;mg/kg.<ref>{{cite journal | vauthors = Fitzgerald KT, Bronstein AC, Newquist KL | title = Marijuana poisoning | journal = Topics in Companion Animal Medicine | volume = 28 | issue = 1 | pages = 8–12 | date = February 2013 | pmid = 23796481 | doi = 10.1053/j.tcam.2013.03.004 }}</ref> According to ''[[The Merck Index]]'',<ref name=merck1996>1996. ''The Merck Index'', 12th ed., Merck & Co., Rahway, New Jersey</ref> the {{LD50}} of THC (the dose which causes the death of 50% of individuals) is 1270&nbsp;mg/kg for male rats and 730&nbsp;mg/kg for female rats from oral consumption in sesame oil, and 42&nbsp;mg/kg for rats from inhalation.<ref>{{cite web |title=Cannabis Chemistry |url=http://www.erowid.org/plants/cannabis/cannabis_chemistry.shtml |publisher=Erowid.org |access-date=29 July 2007 |archive-date=14 March 2007 |archive-url=https://web.archive.org/web/20070314000115/http://www.erowid.org/plants/cannabis/cannabis_chemistry.shtml |url-status=live }}</ref>
<!-- A typical marijuana "joint" contains less than 10&nbsp;mg of THC, and one would have to smoke thousands of those in a short period of time to approach toxic levels. According to a 2006 [[United Kingdom]] government report, using cannabis is much less dangerous than tobacco, prescription drugs, and alcohol in social harms, physical harm, and addiction.<ref name="UK government report">{{Cite news |url=http://news.bbc.co.uk/1/shared/bsp/hi/pdfs/31_07_06_drugsreport.pdf |title=UK government report|publisher=House of Commons Science and Technology Committee |date=18 July 2006 |via=[[BBC News]] |access-date=29 August 2006 |format=PDF}} The information is not in the report, but in evidence submitted to the committee. Needs correcting – can cite Lancet paper by David Nutt et al.</ref>-->

Cannabinoids and other molecules present in cannabis can alter the metabolism of other drugs, especially due to competition for clearing metabolic pathways such as [[cytochromes]] [[CYP450]], thus leading to drug toxicities by medications that the person consuming cannabis may be taking.<ref>{{Cite journal|doi=10.2174/1389200217666151210142051 |pmid=26651971 |title=Cannabinoids and Cytochrome P450 Interactions |year=2016 |last1=Zendulka |first1=Ondřej |last2=Dovrtělová |first2=Gabriela |last3=Nosková |first3=Kristýna |last4=Turjap |first4=Miroslav |last5=Šulcová |first5=Alexandra |last6=Hanuš |first6=Lumír |last7=Juřica |first7=Jan |journal=Current Drug Metabolism |volume=17 |issue=3 |pages=206–226 }}</ref>