Editing Centriole (section)

==Centriole duplication==
Before [[DNA replication]], cells contain two centrioles, an older '''mother centriole''', and a younger '''daughter centriole'''. During [[cell division]], a new centriole grows at the proximal end of both mother and daughter centrioles. After duplication, the two centriole pairs (the freshly assembled centriole is now a daughter centriole in each pair) will remain attached to each other [[orthogonal]]ly until [[mitosis]]. At that point the mother and daughter centrioles separate dependently on an [[enzyme]] called [[separase]].<ref>{{Cite journal|pmid=16862117|year=2006|last1=Tsou|first1=MF|last2=Stearns|first2=T|title=Mechanism limiting centrosome duplication to once per cell cycle|volume=442|issue=7105|pages=947–51|doi=10.1038/nature04985|journal=Nature|bibcode = 2006Natur.442..947T |s2cid=4413248}}</ref>

The two centrioles in the centrosome are tied to one another. The mother centriole has radiating appendages at the [[Anatomical terms of location#Proximal and distal|distal]] end of its long axis and is attached to its daughter at the [[Anatomical terms of location#Proximal and distal|proximal]] end. Each daughter cell formed after cell division will inherit one of these pairs. Centrioles start duplicating when DNA replicates.<ref name="Salisbury-2002" />