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===Mitotic phase (chromosome separation)=== <!--[[Mitotic phase]] and [[M phase]] redirect here--> {{Main|Mitosis}} The relatively brief ''M phase'' consists of nuclear division ([[karyokinesis]]) and division of cytoplasm ([[cytokinesis]]). M phase is complex and highly regulated. The sequence of events is divided into phases, corresponding to the completion of one set of activities and the start of the next. These phases are sequentially known as: *[[prophase]] *[[prometaphase]] *[[metaphase]] *[[anaphase]] *[[telophase]] [[Image:Mitosis Stages.svg|center|900px|A diagram of the mitotic phases]] Mitosis is the process by which a [[eukaryotic]] cell separates the [[chromosome]]s in its [[cell nucleus]] into two identical sets in two nuclei.<ref>{{cite web | vauthors = Rubenstein I, Wick SM | title = Cell | website = World Book Online Reference Center | date = 2008 | url = http://www.worldbookonline.com/wb/Article?id%3Dar102240 | access-date = 2009-07-10 | url-status = dead | archive-url = https://web.archive.org/web/20110530132021/http://www.worldbookonline.com/wb/Article?id=ar102240 | archive-date = 30 May 2011}}</ref> During the process of mitosis the pairs of [[chromosomes]] condense ([[chromosome condensation]]) and attach to [[microtubule]]s that pull the [[sister chromatids]] to opposite sides of the cell.<ref name = "Maton_1997">{{cite book | vauthors = Maton A, Lahart D, Hopkins J, Warner MQ, Johnson S, Wright JD | title = Cells: Building Blocks of Life | publisher = Prentice Hall | year = 1997 | location = New Jersey | pages = [https://archive.org/details/cellsbuildingblo00mato/page/70 70β4] | isbn = 978-0-13-423476-2 | url = https://archive.org/details/cellsbuildingblo00mato/page/70 }}</ref> Mitosis occurs exclusively in [[eukaryote|eukaryotic]] cells, but occurs in different ways in different species. For example, animal cells undergo an "open" mitosis, where the [[nuclear envelope]] breaks down before the chromosomes separate, while [[fungi]] such as ''[[Aspergillus nidulans]]'' and ''[[Saccharomyces cerevisiae]]'' ([[yeast]]) undergo a "closed" mitosis, where chromosomes divide within an intact [[cell nucleus]].<ref>{{cite journal | vauthors = De Souza CP, Osmani SA | title = Mitosis, not just open or closed | journal = Eukaryotic Cell | volume = 6 | issue = 9 | pages = 1521β1527 | date = September 2007 | pmid = 17660363 | pmc = 2043359 | doi = 10.1128/EC.00178-07 }}</ref>
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