Editing Brugada syndrome (section)

=== Provocation testing ===
Some medications, particularly antiarrhythmic drugs that block the cardiac sodium current ''I''<sub>Na,</sub> can reveal a Type 1 Brugada pattern in susceptible people.  These drugs can be used to help make a diagnosis in those suspected of having Brugada syndrome (e.g. survivors of an unexplained cardiac arrest, family members of a person with Brugada syndrome) but in whom a diagnostic ECG pattern has not been seen.<ref name="Pol2017" />  In these cases, sodium current blocking medications can be given in a controlled environment.<ref name="Obeyesekere_2011">{{cite journal | vauthors = Obeyesekere MN, Klein GJ, Modi S, Leong-Sit P, Gula LJ, Yee R, Skanes AC, Krahn AD | title = How to perform and interpret provocative testing for the diagnosis of Brugada syndrome, long-QT syndrome, and catecholaminergic polymorphic ventricular tachycardia | journal = Circulation: Arrhythmia and Electrophysiology | volume = 4 | issue = 6 | pages = 958–64 | date = December 2011 | pmid = 22203660 | doi = 10.1161/CIRCEP.111.965947 | doi-access = free }}</ref> The most commonly used drugs for this purpose are [[ajmaline]], flecainide, and [[procainamide]], with some suggestions indicating that ajmaline may be the most effective.<ref>{{cite journal | vauthors = Wolpert C, Echternach C, Veltmann C, Antzelevitch C, Thomas GP, Spehl S, Streitner F, Kuschyk J, Schimpf R, Haase KK, Borggrefe M | title = Intravenous drug challenge using flecainide and ajmaline in patients with Brugada syndrome | journal = Heart Rhythm | volume = 2 | issue = 3 | pages = 254–60 | date = March 2005 | pmid = 15851314 | pmc = 1474213 | doi = 10.1016/j.hrthm.2004.11.025 }}</ref> Precaution must be taken in giving these medications as there is a small risk of causing abnormal heart rhythms.<ref name="Obeyesekere_2011" />