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==Types== There are several types of brachydactyly: {| class="wikitable" ! Type !! [[OMIM]] !! Gene !! [[Locus (genetics)|Locus]] !! Also known as |Description |- |Type A1, BDA1|| {{OMIM|112500||none}} || [[IHH (protein)|IHH]] [[BDA1B]] || 5p13.3-p13.2, 2q33-q35 || Brachydactyly type A1 or Farabee-type brachydactyly. |BDA1 is an [[autosomal dominant]] inherited disease. Features include: short or absent [[phalanx bones|phalanges]], extra [[carpal bone]]s, [[Hypoplasia|hypoplastic]] or absent [[ulna]] and short [[metacarpal]] bones. |- |Type A2, BDA2|| {{OMIM|112600||none}} || [[BMPR1B]] [[GDF5]] ||20q11.2, 4q23-q24|| Brachydactyly type A2, Brachymesophalangy II or Brachydactyly Mohr-Wriedt type. |Type A2 is a very rare form of brachydactyly. The phalanges of the index fingers and second toes are shortened.<ref name=":0">{{Cite web |last=Brennan |first=Dan |title=What Is Brachydactyly? |url=https://www.webmd.com/a-to-z-guides/what-is-brachydactyly |access-date=2022-10-13 |website=WebMD |language=en |archive-date=2022-10-13 |archive-url=https://web.archive.org/web/20221013094747/https://www.webmd.com/a-to-z-guides/what-is-brachydactyly |url-status=live }}</ref> |- |Type A3, BDA3|| {{OMIM|112700||none}} || [[HOXD13]]|| || Brachydactyly type A3, brachymesophalangy V or brachydactyly-clinodactyly. |Type A3 only shortens the middle bone of the little finger.<ref name=":0" /> |- |Type A4, BDA4|| {{OMIM|112800||none}} || ''[[HOXD13]]''|| 2q31-q32|| Brachydactyly type A4, brachymesophalangy II and V or brachydactyly temtamy type. |Characterized by shortened 2nd and 5th fingers and an absence of the 2nd-5th lateral toes.<ref name=":0" /> |- |Type A5, BDA5|| {{OMIM|112900||none}} || || || Brachydactyly type A5 nail dysplasia. | |- |Type A6, BDA6|| {{OMIM|112910||none}} || || || Brachydactyly type A6 or Osebold-Remondini syndrome. | |- |Type A7, BDA7|| || || || Brachydactyly type A7 or brachydactyly smorgasbord type.<ref>{{cite journal |vauthors=Meiselman SA, Berkenstadt M, Ben-Ami T, Goodman RM |title=Brachydactyly type A-7 (Smorgasbord): a new entity |journal=Clin. Genet. |volume=35 |issue=4 |pages=261β7 |year=1989 |pmid=2714013 |doi= 10.1111/j.1399-0004.1989.tb02940.x|s2cid=30099363 }}</ref> | |- |Type B, BDB (or BDB1)|| {{OMIM|113000||none}} || [[ROR2]] || 9q22|| Brachydactyly type B or [[Cooks syndrome]]. |Type B affects the final bones of all eight fingers. It causes the bone to be shortened or missing entirely. The same thing happens to the corresponding toes. The final thumb bones and big toe bones may be split or flatter than average.<ref name=":0" /> |- |Type C, BDC|| {{OMIM|113100||none}} || [[GDF5]] || 20q11.2|| Brachydactyly type C or Brachydactyly Haws type. |This rare form of brachydactyly only affects three fingers on each hand. The index, middle, and little finger will have their middle bone shortened. The ring finger will not be affected. As a result, type C brachydactyly will leave the ring finger as the longest on the hand.<ref name=":0" /> |- |[[Brachydactyly type D|Type D]], BDD|| {{OMIM|113200||none}} || [[HOXD13]] || 2q31-q32 || Brachydactyly type D. "Stub Thumb" Referred to inaccurately as "[[Nail clubbing|clubbed]] thumbs".<ref>{{Cite web |date=15 July 2021 |title=Clubbing of the Nails: Background, Pathophysiology, Epidemiology |url=http://emedicine.medscape.com/article/1105946-overview |access-date=18 September 2015 |archive-date=20 November 2021 |archive-url=https://web.archive.org/web/20211120022705/https://emedicine.medscape.com/article/1105946-overview |url-status=live }}</ref> |Most common form of brachydactyly. It shortens the final bone in the thumbs and does not affect the fingers at all.<ref name=":0" /> |- |Type E, BDE|| {{OMIM|113300||none}} || [[HOXD13]] || 2q31-q32 || Brachydactyly type E. |This is the rarest form of brachydactyly. It is most often part of another condition that someone is born with. Type E shortens the bones in the hands and feet along with the bottom bone in the fingers. Instead of making the fingers and toes look shorter, it makes the hands and feet look smaller.<ref name=":0" /> |- |Type B and E|| {{OMIM|112440||none}} || [[ROR2]] [[HOXD13]] || 9q22, 2q31-q32 || Brachydactyly types B and E combined, Ballard syndrome or Pitt-Williams brachydactyly. | |- |Type A1B, BDA1B|| {{OMIM|607004||none}} || || 5p13.3-p13.2 || Brachydactyly type A1, B. | |- |}
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