Editing Bone (section)

====Osteoblast====
[[File:Active osteoblasts.jpg|thumb|[[Micrograph|Light micrograph]] of [[Bone decalcification|decalcified]] cancellous bone tissue displaying osteoblasts actively synthesizing osteoid, containing two osteocytes.]]

[[Osteoblast]]s are mononucleate bone-forming cells. They are located on the surface of osteon seams and make a [[protein]] mixture known as [[osteoid]], which mineralizes to become bone.{{sfn|Young|2006|pp=189–190}} The osteoid seam is a narrow region of a newly formed organic matrix, not yet mineralized, located on the surface of a bone. Osteoid is primarily composed of Type I [[collagen]]. Osteoblasts also manufacture [[hormone]]s, such as [[prostaglandin]]s, to act on the bone itself. The osteoblast creates and repairs new bone by actually building around itself. First, the osteoblast puts up collagen fibers. These collagen fibers are used as a framework for the osteoblasts' work. The osteoblast then deposits calcium phosphate which is hardened by [[hydroxide]] and [[bicarbonate]] ions. The brand-new bone created by the osteoblast is called [[osteoid]].<ref>{{cite web | url = http://depts.washington.edu/bonebio/bonAbout/bonecells.html | archive-url = https://web.archive.org/web/20110807200120/http://depts.washington.edu/bonebio/bonAbout/bonecells.html | archive-date = 7 August 2011 | title = The O' Cells | work = Bone Cells | publisher = The University of Washington | date = 3 April 2013 }}</ref> Once the osteoblast is finished working it is actually trapped inside the bone once it hardens. When the osteoblast becomes trapped, it becomes known as an osteocyte. Other osteoblasts remain on the top of the new bone and are used to protect the underlying bone, these become known as bone lining cells.<ref>{{cite journal | vauthors = Wein MN |date=28 April 2017 |title= Bone Lining Cells: Normal Physiology and Role in Response to Anabolic Osteoporosis Treatments |journal=Current Molecular Biology Reports |volume=3 |issue= 2|pages= 79–84 |doi= 10.1007/s40610-017-0062-x|s2cid= 36473110 }}</ref>