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===Cancer=== Spread of cancer to the bone or spinal cord can lead to back pain. Bone is one of the most common sites of metastatic lesions. Patients typically have a history of malignancy. Common types of cancer that present with back pain include [[multiple myeloma]], [[lymphoma]], [[leukemia]], spinal cord tumors, primary vertebral tumors and [[prostate cancer]].<ref name=":16">{{Cite book|title=Symptom to diagnosis : an evidence-based guide| vauthors = Stern SD |isbn=978-0071803441|oclc=894996548|date = 2014 |edition=3|page=| publisher = McGraw-Hill Education }}{{page needed|date=February 2021}}</ref> Back pain is present in 29% of patients with systemic cancer.<ref name=":11" /> Unlike other causes of back pain that commonly affect the lumbar spine, the thoracic spine is most commonly affected.<ref name=":11" /> The pain can be associated with systemic symptoms such as weight loss, chills, fever, nausea and vomiting.<ref name=":11" /> Unlike other causes of back pain, [[neoplasm]]-associated back pain is constant, dull, poorly localized and worsens with rest. [[Metastasis]] to the bone also increases the risk of [[Spinal cord compression|spinal-cord compression]] or vertebral fractures that require emergency surgical treatment.<ref>{{Cite journal |last1=Tsukamoto |first1=Shinji |last2=Kido |first2=Akira |last3=Tanaka |first3=Yasuhito |last4=Facchini |first4=Giancarlo |last5=Peta |first5=Giuliano |last6=Rossi |first6=Giuseppe |last7=Mavrogenis |first7=Andreas F. |date=2021-08-29 |title=Current Overview of Treatment for Metastatic Bone Disease |journal=Current Oncology |language=en |volume=28 |issue=5 |pages=3347β3372 |doi=10.3390/curroncol28050290 |doi-access=free |issn=1718-7729 |pmc=8482272 }}</ref>
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