Editing Asparagine (section)

== Function ==
Asparagine synthetase is required for normal development of the brain.<ref>{{cite journal | vauthors = Ruzzo EK, Capo-Chichi JM, Ben-Zeev B, Chitayat D, Mao H, Pappas AL, Hitomi Y, Lu YF, Yao X, Hamdan FF, Pelak K, Reznik-Wolf H, Bar-Joseph I, Oz-Levi D, Lev D, Lerman-Sagie T, Leshinsky-Silver E, Anikster Y, Ben-Asher E, Olender T, Colleaux L, Décarie JC, Blaser S, Banwell B, Joshi RB, He XP, Patry L, Silver RJ, Dobrzeniecka S, Islam MS, Hasnat A, Samuels ME, Aryal DK, Rodriguiz RM, Jiang YH, Wetsel WC, McNamara JO, Rouleau GA, Silver DL, Lancet D, Pras E, Mitchell GA, Michaud JL, Goldstein DB | display-authors = 6 | title = Deficiency of asparagine synthetase causes congenital microcephaly and a progressive form of encephalopathy | journal = Neuron | volume = 80 | issue = 2 | pages = 429–41 | date = October 2013 | pmid = 24139043 | pmc = 3820368 | doi = 10.1016/j.neuron.2013.08.013 }}</ref> Asparagine is also involved in [[protein synthesis]] during replication of [[Poxviridae|poxviruses]].<ref>{{cite journal | vauthors = Pant A, Cao S, Yang Z | title = Asparagine Is a Critical Limiting Metabolite for Vaccinia Virus Protein Synthesis during Glutamine Deprivation | journal = Journal of Virology | volume = 93 | issue = 13 | pages = e01834–18, /jvi/93/13/JVI.01834–18.atom | date = July 2019 | pmid = 30996100 | pmc = 6580962 | doi = 10.1128/JVI.01834-18 | veditors = Shisler JL }}</ref>

The addition of [[N-acetylglucosamine|''N''-acetylglucosamine]] to asparagine is performed by [[oligosaccharyltransferase]] enzymes in the [[endoplasmic reticulum]].<ref>{{cite journal | vauthors = Burda P, Aebi M | title = The dolichol pathway of N-linked glycosylation | journal = Biochimica et Biophysica Acta (BBA) - General Subjects | volume = 1426 | issue = 2 | pages = 239–57 | date = January 1999 | pmid = 9878760 | doi = 10.1016/S0304-4165(98)00127-5 }}</ref> This glycosylation is involved in protein structure<ref>{{cite journal | vauthors = Imperiali B, O'Connor SE | title = Effect of N-linked glycosylation on glycopeptide and glycoprotein structure | journal = Current Opinion in Chemical Biology | volume = 3 | issue = 6 | pages = 643–9 | date = December 1999 | pmid = 10600722 | doi = 10.1016/S1367-5931(99)00021-6 }}</ref> and function.<ref>{{cite journal | vauthors = Patterson MC | title = Metabolic mimics: the disorders of N-linked glycosylation | journal = Seminars in Pediatric Neurology | volume = 12 | issue = 3 | pages = 144–51 | date = September 2005 | pmid = 16584073 | doi = 10.1016/j.spen.2005.10.002 }}</ref>