Editing Appendix (anatomy) (section)

===Appendicitis===
{{Main|Appendicitis}}
[[Appendicitis]] is a condition characterized by [[inflammation]] of the appendix. Pain often begins in the center of the abdomen, corresponding to the appendix's development as part of the embryonic [[midgut]]. This pain is typically a dull, poorly localized, [[viscus|visceral]] pain.<ref name="Biology 92-98">{{Cite book|author=Miller R., Kenneth |author2=Levine, Joseph  |title=Biology |publisher=[[Prentice Hall]] |year=2002 |isbn=978-0-13-050730-3 |pages=92–98}}</ref>

As the inflammation progresses, the pain begins to localize more clearly to the right lower quadrant, as the [[peritoneum]] becomes inflamed. This peritoneal inflammation, or [[peritonitis]], results in [[rebound tenderness]] (pain upon removal of pressure rather than the application of pressure). In particular, it presents at [[McBurney's point]], 1/3 of the way along a line drawn from the [[anterior superior iliac spine]] to the [[navel|umbilicus]]. Typically, point (skin) pain is not present until the [[parietal peritoneum]] is inflamed, as well. Fever and an immune system response are also characteristic of appendicitis.<ref name="Biology 92-98"/> Other signs and symptoms may include [[nausea]] and vomiting, low-grade fever that may get worse, [[constipation]] or [[diarrhea]], abdominal bloating, or [[flatulence]].<ref name=Mayo-Appendicitis>{{cite web |url=https://www.mayoclinic.org/diseases-conditions/appendicitis/symptoms-causes/syc-20369543 |title=Appendicitis - Symptoms and causes - Mayo Clinic |author=<!--Not stated--> |website=mayoclinic.org |publisher=[[Mayo Clinic]] |access-date=29 December 2020 |url-status=live |archive-url=https://web.archive.org/web/20201125012725/https://www.mayoclinic.org/diseases-conditions/appendicitis/symptoms-causes/syc-20369543 |archive-date=25 November 2020 }}</ref>

Appendicitis usually requires the removal of the inflamed appendix, in an [[appendectomy]] either by [[laparotomy]] or [[laparoscopy]]. Untreated, the appendix may rupture, leading to [[peritonitis]], followed by [[septic shock|shock]], and, if still untreated, death.<ref name="Biology 92-98"/>