Editing Antiviral drug (section)

=====Uncoating inhibitors=====
Inhibitors of uncoating have also been investigated.<ref name="pmid10325536">{{cite journal |author=Bishop NE |title=Examination of potential inhibitors of hepatitis A virus uncoating |journal=Intervirology |volume=41 |issue=6 |pages=261–71 |year=1998 |pmid=10325536 |doi= 10.1159/000024948|s2cid=21222121 }}</ref><ref name="pmid1850030">{{cite journal |vauthors=Almela MJ, González ME, Carrasco L |title=Inhibitors of poliovirus uncoating efficiently block the early membrane permeabilization induced by virus particles |journal=J. Virol. |volume=65 |issue=5 |pages=2572–77 |date=May 1991 |pmid=1850030 |pmc=240614|doi=10.1128/JVI.65.5.2572-2577.1991 }}</ref>

[[Amantadine]] and [[rimantadine]] have been introduced to combat influenza. These agents act on penetration and uncoating.<ref name="isbn0-7817-4673-6">{{cite book |author1=Beringer, Paul |author2=Troy, David A. |author3=Remington, Joseph P. |title=Remington, the science and practice of pharmacy |publisher=Lippincott Williams & Wilkins |location=Hagerstwon, MD |year=2006 |page=1419 |isbn=978-0-7817-4673-1}}</ref>

[[Pleconaril]] works against [[rhinovirus]]es, which cause the [[common cold]], by blocking a pocket on the surface of the virus that controls the uncoating process. This pocket is similar in most strains of rhinoviruses and [[enterovirus]]es, which can cause diarrhea, [[meningitis]], [[conjunctivitis]], and [[encephalitis]].<ref>{{cite journal |title=Activity of Pleconaril against Enteroviruses |author1=Daniel C. Pevear |author2=Tina M. Tull |author3= Martin E. Seipel |journal=Antimicrobial Agents and Chemotherapy |year=1999|volume=43 |issue=9 |pages=2109–2115 |doi=10.1128/AAC.43.9.2109 |pmid=10471549 |pmc=89431 }}</ref>

Some scientists are making the case that a vaccine against rhinoviruses, the predominant cause of the common cold, is achievable.
Vaccines that combine dozens of varieties of rhinovirus at once are effective in stimulating antiviral antibodies in mice and monkeys, researchers reported in ''[[Nature Communications]]'' in 2016.<ref>{{cite news |url=https://www.nature.com/articles/ncomms12838 |author1=Lee, S. |author2=Nguyen, M. |author3=Currier, M. |title=A polyvalent inactivated rhinovirus vaccine is broadly immunogenic in rhesus macaques |publisher=Nature Communications |year=2016}}</ref>

Rhinoviruses are the most common cause of the common cold; other viruses such as [[respiratory syncytial virus]], [[parainfluenza virus]] and [[adenoviruses]] can cause them too.<ref>{{cite web |url=https://bready.blog.ranftl.org/health/common-cold-causes |title=Common Cold Causes: Rhinoviruses and More |access-date=8 January 2022 |archive-date=8 January 2022 |archive-url=https://web.archive.org/web/20220108160711/https://bready.blog.ranftl.org/health/common-cold-causes |url-status=dead }}</ref> Rhinoviruses also exacerbate asthma attacks. Although rhinoviruses come in many varieties, they do not drift to the same degree that influenza viruses do. A mixture of 50 inactivated rhinovirus types should be able to stimulate neutralizing antibodies against all of them to some degree.<ref>{{cite web |url=https://grantome.com/grant/NIH/R43-AI131750-01 |title=Development of polyvalent inactivated rhinovirus vaccine |year=2017|last1=Tang |first1=Roderick |last2=Moore |first2=Martin }}</ref>