Editing Antidepressant (section)

==== Post–traumatic stress disorder ====
Antidepressants are one of the treatment options for [[Post-traumatic stress disorder|PTSD]]. However, their efficacy is not well established. Paroxetine and sertraline have been FDA approved for the treatment of PTSD. Paroxetine has slightly higher response and remission rates than sertraline for this condition. However, neither drug is considered very helpful for a broad patient demographic. Fluoxetine and venlafaxine are used off-label. Fluoxetine has produced unsatisfactory mixed results. Venlafaxine showed response rates of 78%, which is significantly higher than what paroxetine and sertraline achieved. However, it did not address as many symptoms of PTSD as paroxetine and sertraline, in part due to the fact that venlafaxine is an [[Serotonin–norepinephrine reuptake inhibitor|SNRI]]. This class of drugs inhibits the reuptake of norepinephrine, which may cause anxiety in some patients. Fluvoxamine, escitalopram, and citalopram were not well-tested for this disorder. [[Monoamine oxidase inhibitor|MAOIs]], while some of them may be helpful, are not used much because of their unwanted side effects. This leaves paroxetine and sertraline as acceptable treatment options for some people, although more effective antidepressants are needed.<ref>{{cite journal|vauthors=Alexander W|title=Pharmacotherapy for Post-traumatic Stress Disorder in Combat Veterans: Focus on Antidepressants and Atypical Antipsychotic Agents|journal=P & T|volume=37|issue=1|pages=32–38|date=January 2012|pmid=22346334|pmc=3278188}}</ref>