Editing Animal testing (section)

=== Zebrafish ===
[[Zebrafish]] are commonly used for the basic study and development of various [[cancer]]s. Used to explore the immune system and genetic strains. They are low in cost, small in size, have a fast reproduction rate, and able to observe cancer cells in real time. Humans and zebrafish share [[neoplasm]] similarities which is why they are used for research. The National Library of Medicine shows many examples of the types of cancer zebrafish are used in. The use of zebrafish have allowed them to find differences between MYC-driven pre-B vs T-ALL and be exploited to discover novel pre-B ALL therapies on acute lymphocytic [[leukemia]].<ref>{{cite journal |last1=Li |first1=Zhitao |last2=Zheng |first2=Wubin |last3=Wang |first3=Hanjin |last4=Cheng |first4=Ye |last5=Fang |first5=Yijiao |last6=Wu |first6=Fan |last7=Sun |first7=Guoqiang |last8=Sun |first8=Guangshun |last9=Lv |first9=Chengyu |last10=Hui |first10=Bingqing |date=2021-03-15 |title=Application of Animal Models in Cancer Research: Recent Progress and Future Prospects |journal=Cancer Management and Research |volume=13 |pages=2455–2475 |doi=10.2147/CMAR.S302565 |issn=1179-1322 |pmc=7979343 |pmid=33758544 |doi-access=free }}</ref><ref>{{cite journal |last1=Workman |first1=P. |last2=Aboagye |first2=E. O. |last3=Balkwill |first3=F. |last4=Balmain |first4=A. |last5=Bruder |first5=G. |last6=Chaplin |first6=D. J. |last7=Double |first7=J. A. |last8=Everitt |first8=J. |last9=Farningham |first9=D. a. H. |last10=Glennie |first10=M. J. |last11=Kelland |first11=L. R. |date=2010-05-25 |title=Guidelines for the welfare and use of animals in cancer research |journal=British Journal of Cancer |volume=102 |issue=11 |pages=1555–1577 |doi=10.1038/sj.bjc.6605642 |issn=1532-1827 |pmc=2883160 |pmid=20502460}}</ref>

The National Library of Medicine also explains how a neoplasm is difficult to diagnose at an early stage. Understanding the molecular mechanism of digestive tract tumorigenesis and searching for new treatments is the current research. Zebrafish and humans share similar gastric cancer cells in the gastric cancer xenotransplantation model. This allowed researchers to find that Triphala could inhibit the growth and metastasis of gastric cancer cells. Since zebrafish liver cancer genes are related with humans they have become widely used in liver cancer search, as will as many other cancers.<ref>{{cite journal |last1=Tsering |first1=Jokyab |last2=Hu |first2=Xianda |date=2018 |title=Triphala Suppresses Growth and Migration of Human Gastric Carcinoma Cells In Vitro and in a Zebrafish Xenograft Model |journal=BioMed Research International |volume=2018 |pages=7046927 |doi=10.1155/2018/7046927 |issn=2314-6141 |pmc=6311269 |pmid=30643816|doi-access=free }}</ref>

[[File:Danio rerio lab left.JPG|thumb|[[Zebrafish]] are a freshwaterfish and belong to the minnow family. They are commonly used for cancer research.]]