Editing Acute disseminated encephalomyelitis (section)

====Multiphasic disseminated encephalomyelitis====

When the person has more than one demyelinating episode of ADEM, the disease is then called recurrent disseminated encephalomyelitis or multiphasic disseminated encephalomyelitis<ref name="Dale_2000" /> (MDEM).

It has been found that anti-[[Myelin oligodendrocyte glycoprotein|MOG]] auto-antibodies are related to this kind of ADEM<ref>{{cite journal | vauthors = Baumann M, Hennes EM, Schanda K, Karenfort M, Bajer-Kornek B, Diepold K, Fiedler B, Marquardt I, Strautmanis J, Vieker S, Reindl M | display-authors = 6 | title = OP65–3006: Clinical characteristics and neuroradiological findings in children with multiphasic demyelinating encephalomyelitis and MOG antibodies. | journal = European Journal of Paediatric Neurology | date = May 2015 | volume = 19 | issue = supplement 1 | pages = S21 | doi = 10.1016/S1090-3798(15)30066-0 | series = Abstracts of the 11th EPNS Congress }}</ref>

Another variant of ADEM in adults has been described, also related to anti-MOG auto-antibodies, has been named fulminant disseminated encephalomyelitis, and it has been reported to be clinically ADEM, but showing MS-like lesions on autopsy.<ref name="DiPauli_2015"/> It has been classified inside the [[anti-MOG associated inflammatory demyelinating diseases]].<ref>{{cite journal | vauthors = Baumann M, Hennes EM, Schanda K, Karenfort M, Kornek B, Seidl R, Diepold K, Lauffer H, Marquardt I, Strautmanis J, Syrbe S, Vieker S, Höftberger R, Reindl M, Rostásy K | display-authors = 6 | title = Children with multiphasic disseminated encephalomyelitis and antibodies to the myelin oligodendrocyte glycoprotein (MOG): Extending the spectrum of MOG antibody positive diseases | journal = Multiple Sclerosis | volume = 22 | issue = 14 | pages = 1821–29 | date = December 2016 | pmid = 26869530 | doi = 10.1177/1352458516631038 | s2cid = 30428892 }}</ref>