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== Births == [[File:Maria von Portugal, Anthonis Mor.jpg|thumb|110px|[[Maria of Portugal, Duchess of Viseu]]]] * [[March 21]] – [[Maurice, Elector of Saxony]] (d. [[1553]])<ref>{{cite book |last1=Beach |first1=Frederick Converse |last2=Morgan |first2=Forrest |last3=Rines |first3=George Edwin |last4=Roe |first4=Edward Thomas |last5=Dole |first5=Nathan Haskell |last6=Copeland |first6=Thomas Campbell |title=The Encyclopedia Americana |date=1903 |publisher=Americana Company |page=94 |url=https://books.google.com/books?id=n9FCAQAAMAAJ&q=%20%2221%20march%201521%22 |access-date=26 July 2023 |language=en}}</ref> * [[April 5]] – [[Francesco Laparelli]], Italian architect (d. [[1570]])<ref>{{cite book |title=Nuovo dizionario istorico |date=1791 |volume=XV|publisher=per Michele Morelli |location=Naples |page=218 |url=https://books.google.com/books?id=W95oiVI6nyUC&dq=Francesco+Laparelli+%225+aprile+1521%22&pg=PA218 |access-date=26 July 2023 |language=it}}</ref> * [[April 14]] – [[Johann Marbach]], German theologian (d. [[1581]])<ref>{{cite book |last1=Horning |first1=Wilhelm |title=Dr. Johann Marbach, Pfarrer zu St. Nikolai, Münsterprediger, Professor und Präsident des Luth. Kirchenconvents in Strassburg, 1545-1581 |date=1887 |publisher=C.A. Vomhoff |location=Strasbourg |page=11 |url=https://books.google.com/books?id=NJLP60wdPSMC&q=%2214%20april%201521%22 |access-date=26 July 2023 |language=de}}</ref> * [[April 18]] – [[François de Coligny d'Andelot]], French general (d. [[1569]])<ref>{{cite book |last1=Vindry |first1=Fleury |title=Dictionnaire de l'état-major français au XVIe siècle |date=1901 |publisher=Castanet |page=161 |url=https://books.google.com/books?id=idKajpeREDkC&dq=Fran%C3%A7ois+de+Coligny+d%27Andelot+%2218+avril+1521%22&pg=PA161 |access-date=26 July 2023 |language=fr}}</ref> * [[May 8]] – [[Petrus Canisius]], Dutch Jesuit (d. [[1597]])<ref>{{cite web |title=St. Peter Canisius |url=https://www.newadvent.org/cathen/11756c.htm |website=www.newadvent.org |access-date=26 July 2023}}</ref> * [[May 10]] – [[John Ernest, Duke of Saxe-Coburg]], (d. [[1553]])<ref>{{cite book |title=Allgemeine deutsche biographie |date=1881 |volume=14|publisher=Duncker und Humblot |page=369 |url=https://books.google.com/books?id=15SjLCe9htcC&dq=Johann+Ernst+%2210+mai+1521%22&pg=PA369 |access-date=26 July 2023 |language=de}}</ref> * [[June 8]] – [[Maria of Portugal, Duchess of Viseu]], daughter of King Manuel I (d. [[1577]])<ref>{{cite book |last1=Vasconcellos |first1=Carolina Michaëlis de |title=A infanta D. Maria de Portugal (1521-1577) e suas damas |date=1902 |publisher=Typ. a vapor de A. J. de Souza & irmão |page=17 |url=https://books.google.com/books?id=kD5AAAAAYAAJ&dq=Maria+de+Portugal+%228+de+junho+de+1521%22&pg=PA17 |access-date=26 July 2023 |language=pt-BR}}</ref> * [[June 21]] – [[John II, Duke of Schleswig-Holstein-Haderslev]] (d. [[1580]])<ref>{{cite book |last1=Bricka |first1=Carl Frederik |title=Dansk biografisk lexikon |date=1892 |volume=6|publisher=F. Hegel & Søn |page=569 |url=https://books.google.com/books?id=97lAAAAAYAAJ&dq=Hans+den+%C3%86ldre+%2229+juni+1521%22&pg=PA569 |access-date=26 July 2023 |language=da}}</ref> * [[August 4]] – [[Pope Urban VII]] (d. [[1590]])<ref>{{cite book|author=Grolier Incorporated|title=The encyclopedia Americana|url=https://books.google.com/books?id=gWENAQAAMAAJ|year=1997|publisher=Grolier Incorporated|page=18|isbn=9780717201303}}</ref> * [[August 19]] – [[Lodovico Guicciardini]], Italian historian (d. [[1589]])<ref>{{cite book |last1=Fantoni |first1=Marcello |title=Il Rinascimento italiano e l'Europa |date=2005 |publisher=Fondazione Cassamarca |isbn=978-88-89527-17-7 |page=165 |url=https://books.google.com/books?id=YOsWAQAAIAAJ&q=%2219%20agosto%201521%22 |access-date=26 July 2023 |language=it}}</ref><ref>{{cite web |title=Guicciardini, Lodovico |url=https://www.oxfordartonline.com/groveart/display/10.1093/gao/9781884446054.001.0001/oao-9781884446054-e-7000035507 |website=Grove Art Online |year=2003 |access-date=26 July 2023 |language=en |doi=10.1093/gao/9781884446054.article.T035507}}</ref> * [[October 1]] – [[Frederick Magnus I, Count of Solms-Laubach]], (d. [[1561]]) * [[November 21]] – [[Edmund Sheffield, 1st Baron Sheffield]], English baron (d. [[1549]])<ref>{{cite ODNB |title=Sheffield, Edmund, first Baron Sheffield |url=https://www.oxforddnb.com/display/10.1093/ref:odnb/9780198614128.001.0001/odnb-9780198614128-e-25292|year=2004 |access-date=26 July 2023 |language=en |doi=10.1093/ref:odnb/25292}}</ref> * [[November 29]] – [[Marcantonio Maffei]], Italian Catholic archbishop and cardinal (d. [[1583]])<ref>{{cite web |title=The Cardinals of the Holy Roman Church - Biographical Dictionary - Consistory of May 17, 1570 |url=https://cardinals.fiu.edu/bios1570.htm#Maffei |website=cardinals.fiu.edu |access-date=26 July 2023}}</ref> * [[December 1]] – [[Takeda Shingen]], Japanese warlord (d. [[1573]]) * [[December 13]] – [[Pope Sixtus V]] (d. [[1590]])<ref>{{cite book|title=RACAR, Revue D'art Canadienne: Canadian Art Review|url=https://books.google.com/books?id=EETrAAAAMAAJ|year=1990|publisher=Society for the Promotion of Art History Publications in Canada|page=18}}</ref> * ''date unknown'' ** [[Anne Askew]], English Protestant martyr (d. [[1546]])<ref>{{cite book |last1=Zahl |first1=Paul |title=Five Women of the English Reformation |date=June 2001 |publisher=Wm. B. Eerdmans Publishing |isbn=978-0-8028-3045-6 |page=27 |url=https://books.google.com/books?id=1zQKcL9l-fsC&q=%221521%22 |access-date=26 July 2023 |language=en}}</ref> ** [[John Aylmer (bishop)|John Aylmer]], English divine (d. [[1594]])<ref>{{cite ODNB |title=Aylmer, John|url=https://www.oxforddnb.com/display/10.1093/ref:odnb/9780198614128.001.0001/odnb-9780198614128-e-935|year=2004 |access-date=26 July 2023 |language=en |doi=10.1093/ref:odnb/935}}</ref> ** [[Sue Harukata]], Japanese retainer and later daimyō under [[Ōuchi Yoshitaka]] (d. [[1555]])<ref>{{cite web |title=陶晴賢(すえはるかた)とは? |url=https://kotobank.jp/word/%E9%99%B6%E6%99%B4%E8%B3%A2-83345 |website=コトバンク |access-date=27 July 2023 |language=ja}}</ref> ** [[Thomas Chaloner (statesman)|Thomas Chaloner]], English statesman and poet (d. [[1565]])<ref>{{cite book |last1=O'Sullivan |first1=Dan |title=The Reluctant Ambassador: The Life and Times of Sir Thomas Chaloner, Tudor Diplomat |date=15 May 2016 |publisher=Amberley Publishing Limited |isbn=978-1-4456-5165-1 |page=12 |url=https://books.google.com/books?id=oMV5DAAAQBAJ&q=1521 |access-date=27 July 2023 |language=en}}</ref> ** [[Philippe de Monte]], Flemish composer (d. [[1603]])<ref>{{cite book |last1=Mann |first1=Brian Richard |title=The secular madrigals of Filippo di Monte, 1521-1603 |date=1983 |publisher=UMI Research Press |location=Ann Arbor |isbn=978-0-8357-1402-0 |page=1 |url=https://archive.org/details/secularmadrigals0000mann/page/n17/mode/2up?q=1521 |access-date=27 July 2023}}</ref> ** [[Rokkaku Yoshikata]], Japanese daimyō (d. [[1598]])<ref>{{cite book |last1=Frederic |first1=Louis |title=Japan Encyclopedia |date=2002 |publisher=Harvard University Press |isbn=978-0-674-01753-5 |page=794 |url=https://books.google.com/books?id=p2QnPijAEmEC&dq=Rokkaku+Yoshikata+%221521%22&pg=PA794 |access-date=27 July 2023 |language=en}}</ref> ** [[Thomas Wyatt the Younger]], English rebel (d. [[1554]])<ref>{{cite ODNB |title=Wyatt, Sir Thomas|url=https://www.oxforddnb.com/display/10.1093/ref:odnb/9780198614128.001.0001/odnb-9780198614128-e-30112|year=2004 |access-date=27 July 2023 |language=en |doi=10.1093/ref:odnb/30112}}</ref> * ''possible'' ** [[Catherine Howard]], fifth queen of [[Henry VIII]] of England, (b. between [[1518]] and [[1524]]; d. [[1542]])<ref>{{cite ODNB |title=Katherine [Catherine] [née Katherine Howard]|url=https://www.oxforddnb.com/display/10.1093/ref:odnb/9780198614128.001.0001/odnb-9780198614128-e-4892|year=2004 |access-date=27 July 2023 |language=en |doi=10.1093/ref:odnb/4892}}</ref>
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