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==== Hepatitis E ==== {{main|Hepatitis E}} Similar to Hepatitis A, [[hepatitis E]] manifests as large outbreaks and epidemics associated with fecal contamination of water sources.<ref name="Harrison's Principles, chapter 360 (Acute Viral)" /> It accounts for more than 55,000 deaths annually with approximately 20 million people worldwide thought to be infected with the virus.<ref name="WHO - Hepatitis E"/> It affects predominantly young adults, causing acute hepatitis.<ref name="Harrison's Principles, chapter 360 (Acute Viral)" /><ref name="HEV FAQs for Health Professionals">{{Cite web|url=https://www.cdc.gov/hepatitis/hev/hevfaq.htm#section1|title=HEV FAQs for Health Professionals {{!}} Division of Viral Hepatitis {{!}} CDC|website=www.cdc.gov|access-date=2016-03-09|url-status=live|archive-url=https://web.archive.org/web/20160308031004/http://www.cdc.gov/hepatitis/hev/hevfaq.htm#section1|archive-date=2016-03-08}}</ref> In infected pregnant women, Hepatitis E infection can lead to fulminant hepatitis with third trimester mortality rates as high as 30%.<ref name="Carroll chapter 35" /><ref name="HEV FAQs for Health Professionals" /> Those with weakened immune systems, such as organ transplant recipients, are also susceptible.<ref name="HEV FAQs for Health Professionals" /> Infection is rare in the United States but rates are high in the developing world (Africa, Asia, Central America, Middle East).<ref name="Harrison's Principles, chapter 360 (Acute Viral)" /><ref name="HEV FAQs for Health Professionals" /> Many genotypes exist and are differentially distributed around the world.<ref name="WHO - Hepatitis E" /> There is some evidence of hepatitis E infection of animals, serving as a reservoir for human infection.<ref name="Carroll chapter 35" />
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