Editing Valproate (section)

==Contraindications==
Contraindications include:
* Pre-existing acute or chronic liver dysfunction or family history of severe [[hepatitis|liver inflammation]] (hepatitis), particularly medicine related.<ref name = TGA>{{cite web|title=Valpro sodium valproate|website=TGA eBusiness Services|publisher=Alphapharm Pty Limited|date=16 December 2013|access-date=14 February 2014|url=https://www.ebs.tga.gov.au/ebs/picmi/picmirepository.nsf/pdf?OpenAgent&id=CP-2010-PI-04603-3|format=PDF|archive-date=27 August 2021|archive-url=https://web.archive.org/web/20210827175359/https://www.ebs.tga.gov.au/ebs/picmi/picmirepository.nsf/pdf?OpenAgent=&id=CP-2010-PI-04603-3|url-status=live}}</ref>
* [[Pregnancy]] 11% risk of birth defects and 30-40% risk of neuro-developmental disabilities which can be permanent<ref name=Birth_defects>{{cite web|title=Update on MHRA review into safe use of valproate|website=gov.uk/ Compendium|date=12 December 2022|url=https://www.gov.uk/government/news/update-on-mhra-review-into-safe-use-of-valproate?fbclid=IwY2xjawF6F3lleHRuA2FlbQIxMAABHSvvOkoGJkhJcVc7C93-lU9ObahoqP1-B6adTob8Whm-4Y3-gTRmSj7R_w_aem_DgIac_yDNVfiatTQ6ckgaQ}}</ref>
* Known [[hypersensitivity]] to valproate or any of the ingredients used in the preparation<ref name = TGA/>
* [[Urea cycle disorders]]<ref name = TGA/>
* Hepatic [[porphyria]]<ref name = TGA/>
* Hepatotoxicity<ref name = TGA/>
* [[Mitochondrial disease]]<ref name = TGA/>
* [[Pancreatitis]]<ref name = TGA/>
* [[Porphyria]]<ref name=EMC>{{cite web|title=Depakote 250mg Tablets - Summary of Product Characteristics|website=electronic Medicines Compendium|publisher=Sanofi|date=28 November 2013|access-date=18 January 2014|url=http://www.medicines.org.uk/emc/medicine/25929/SPC/Depakote+250mg+Tablets/|url-status=live|archive-url=https://web.archive.org/web/20140201115858/http://www.medicines.org.uk/emc/medicine/25929/SPC/Depakote+250mg+Tablets/|archive-date=1 February 2014}}</ref>