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====Hearing loss==== The most common cause of tinnitus is [[hearing loss]]. Hearing loss may have many different causes, but among those with tinnitus, the major cause is [[cochlea]]r injury.<ref name="TriAudiogramSlope">{{cite journal |last1=Schecklmann |first1=Martin |last2=Vielsmeier |first2=Veronika |last3=Steffens |first3=Thomas |last4=Landgrebe |first4=Michael |last5=Langguth |first5=Berthold |last6=Kleinjung |first6=Tobias |last7=Andersson |first7=Gerhard |title=Relationship between Audiometric Slope and Tinnitus Pitch in Tinnitus Patients: Insights into the Mechanisms of Tinnitus Generation |journal=PLOS ONE |date=18 April 2012 |volume=7 |issue=4 |page=e34878 |doi=10.1371/journal.pone.0034878 |pmid=22529949 |pmc=3329543|bibcode=2012PLoSO...734878S |doi-access=free }}</ref> In many cases no underlying cause is identified.<ref name=NIH2014/><ref name=Yew2014>{{cite journal |last1=Yew |first1=KS |title=Diagnostic approach to patients with tinnitus. |journal=American Family Physician |date=15 January 2014 |volume=89 |issue=2 |pages=106β113 |pmid=24444578}}</ref> [[Ototoxicity|Ototoxic]] drugs also may cause subjective tinnitus, as they may cause hearing loss,<ref name="pmid33080070" /> or increase the damage done by exposure to loud noise.<ref name="pmid32334867">{{cite journal |vauthors=Theodoroff SM, Konrad-Martin D |title=Noise: Acoustic Trauma and Tinnitus, the US Military Experience |journal=Otolaryngologic Clinics of North America |volume=53 |issue=4 |pages=543β553 |date=August 2020 |pmid=32334867 |pmc=9015011 |doi=10.1016/j.otc.2020.03.004 |url=}}</ref> This damage may occur even at doses not considered ototoxic.<ref>{{cite book |doi=10.1002/9780470720677.ch9 |chapter=Ototoxic Drugs and Noise |title=Ciba Foundation Symposium 85 β Tinnitus |series=Novartis Foundation Symposia |year=2008 |last1=Don Brown |first1=R. |last2=Penny |first2=Joe E. |last3=Henley |first3=Charles M. |last4=Hodges |first4=Keri B. |last5=Kupetz |first5=Suzyjo A. |last6=Glenn |first6=David W. |last7=Jobe |first7=Phillip C. |volume=85 |pages=151β171 |pmid=7035098 |isbn=978-0-470-72067-7 }}</ref> More than 260 medications have been reported to cause tinnitus as a side effect.<ref>{{cite web |author=Stas Bekman |url=http://stason.org/TULARC/health/body/tinnitus-ringing-ears/6-What-are-some-ototoxic-drugs.html |title=6) What are some ototoxic drugs? |publisher=Stason.org |access-date=26 October 2012 |url-status=live |archive-url=https://web.archive.org/web/20121019184052/http://stason.org/TULARC/health/body/tinnitus-ringing-ears/6-What-are-some-ototoxic-drugs.html |archive-date=19 October 2012 }}</ref> Tinnitus can also occur from the discontinuation of therapeutic doses of [[benzodiazepine]]s. It can sometimes be a protracted symptom of [[benzodiazepine withdrawal syndrome|benzodiazepine withdrawal]] and may persist for many months.<ref name="clinical_manual_of_emergency_psychiatry">{{Cite book |last1=Riba |first1=Michelle B |last2=Ravindranath |first2=Divy |title=Clinical manual of emergency psychiatry |url=https://books.google.com/books?id=l8veL1bDoF8C&pg=PA197 |year=2010 |publisher=American Psychiatric Publishing Inc |location=Washington, DC |isbn=978-1-58562-295-5 |page=197}}</ref><ref name="seizures">{{Cite book |last1=Delanty |first1=Norman |title=Seizures: medical causes and management |url=https://books.google.com/books?id=u2B3SdfE8-gC&pg=RA1-PA187 |year=2001 |publisher=Humana Press |location=Totowa, NJ |isbn=978-0-89603-827-1 |page=187 }}{{Dead link|date=August 2023 |bot=InternetArchiveBot |fix-attempted=yes }}</ref> Medications such as [[bupropion]] may also cause tinnitus.<ref name="pmid20628627">{{cite journal | vauthors = Fornaro M, Martino M | title = Tinnitus psychopharmacology: A comprehensive review of its pathomechanisms and management | journal = Neuropsychiatric Disease and Treatment | volume = 6 | pages = 209β218 | year = 2010 | pmid = 20628627 | pmc = 2898164 | doi = 10.2147/ndt.s10361 | doi-access = free }}</ref>
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