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== Allergy == {{main|Shellfish allergy}} Approximately 1% of the population is estimated to suffer from shellfish allergy,<ref name=Moone2016>{{cite journal |vauthors=Moonesinghe H, Mackenzie H, Venter C, Kilburn S, Turner P, Weir K, Dean T |title=Prevalence of fish and shellfish allergy: A systematic review |journal=Ann Allergy Asthma Immunol |volume=117 |issue=3 |pages=264β72.e4 |date=September 2016 |pmid=27613460 |doi=10.1016/j.anai.2016.07.015 |hdl=10044/1/45844 |hdl-access=free }}</ref> which is more common in teenage and adult life than very early childhood.<ref name=Wai2020>{{cite journal |vauthors=Wai CY, Leung NY, Chu KH, Leung PS, Leung AS, Wong GW, Leung TF |title=Overcoming Shellfish Allergy: How Far Have We Come? |journal=Int J Mol Sci |volume=21 |issue=6 |date=March 2020 |page=2234 |pmid=32210187 |pmc=7139905 |doi=10.3390/ijms21062234 |doi-access=free }}</ref> There is some evidence that shellfish [[Food intolerance|intolerance]] exists in an unknown proportion of the population. The symptoms of this do not include the immune and respiratory symptoms of an allergic reaction, such as hives, hyperventilation, or anaphylaxis, but do involve gastrointestinal distress, such as nausea, abdominal cramps, and diarrhea. <ref>{{Cite journal |last1=Firszt |first1=K. |last2=Sebastien |first2=K. |last3=Gleich |first3=G. J. |last4=Wagner |first4=L. A. |date=February 2012 |title=Delayed Gastrointestinal Symptoms after Ingesting Shrimp in the Absence of IgE Sensitization |url=https://www.jacionline.org/article/S0091-6749(11)02361-X/fulltext |journal=The Journal of Allergy and Clinical Immunology |volume=129 |issue=2|pages=AB170 |doi=10.1016/j.jaci.2011.12.398 }}</ref> Similar symptoms can come from [[foodborne illness]] or as part of a toxic effect.<ref>{{Cite journal |last1=Woo |first1=Chee |last2=Bahna |first2=Sami |date=June 2011 |title=Not all shellfish "allergy" is allergy! |journal=Clinical and Translational Allergy |volume=1 |issue=1 |page=3 |doi=10.1186/2045-7022-1-3 |doi-access=free |pmid=22410209 |pmc=3294628 }}</ref>
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