Editing Sertraline (section)

===Panic disorder===
Sertraline is superior to placebo for the treatment of [[panic disorder]].<ref name="DailyMed"/> The response rate was independent of the dose. In addition to decreasing the frequency of panic attacks by about 80% (vs. 45% for placebo) and decreasing general anxiety, sertraline resulted in an improvement in quality of life on most parameters. The patients rated as "improved" on sertraline reported better quality of life than the ones who "improved" on placebo. The authors of the study argued that the improvement achieved with sertraline is different and of a better quality than the improvement achieved with a placebo.<ref name="pmid10945134">{{cite journal | vauthors = Hirschfeld RM | title = Sertraline in the treatment of anxiety disorders | journal = Depression and Anxiety | volume = 11 | issue = 4 | pages = 139–57 | year = 2000 | pmid = 10945134 | doi = 10.1002/1520-6394(2000)11:4<139::AID-DA1>3.0.CO;2-C | s2cid = 25572278 | doi-access = free }}</ref><ref name="pmid16292466">{{cite journal | vauthors = Clayton AH, Stewart RS, Fayyad R, Clary CM | s2cid = 20606054 | title = Sex differences in clinical presentation and response in panic disorder: pooled data from sertraline treatment studies | journal = Archives of Women's Mental Health | volume = 9 | issue = 3 | pages = 151–7 | date = May 2006 | pmid = 16292466 | doi = 10.1007/s00737-005-0111-y }}</ref> Sertraline is equally effective for men and women,<ref name="pmid16292466" /> and for patients with or without agoraphobia.<ref name="pmid11206597">{{cite journal |vauthors=Pollack MH, Rapaport MH, Clary CM, Mardekian J, Wolkow R |title=Sertraline treatment of panic disorder: response in patients at risk for poor outcome |journal=J Clin Psychiatry |volume=61 |issue=12 |pages=922–7 |date=December 2000 |doi=10.4088/JCP.v61n1206 |pmid=11206597 }}</ref> Previous unsuccessful treatment with [[benzodiazepines]] does not diminish its efficacy.<ref name="pmid11199932">{{cite journal |vauthors=Rapaport MH, Pollack MH, Clary CM, Mardekian J, Wolkow R |title=Panic disorder and response to sertraline: the effect of previous treatment with benzodiazepines |journal=J Clin Psychopharmacol |volume=21 |issue=1 |pages=104–7 |date=February 2001 |pmid=11199932 |doi=10.1097/00004714-200102000-00019 |s2cid=13442642 }}</ref> However, the response rate was lower for the patients with more severe panic.<ref name="pmid11206597"/> Starting treatment simultaneously with sertraline and [[clonazepam]], with subsequent gradual discontinuation of clonazepam, may accelerate the response.<ref name=Amrein>{{cite book | vauthors = Amrein R, Levitan M | title = Panic Disorder | chapter = Benzodiazepines in Panic Disorder | veditors = Nardi AE |publisher= Springer International Publishing |date=2016 |pages=237–253 | doi = 10.1007/978-3-319-12538-1_16 |chapter-url=https://doi.org/10.1007/978-3-319-12538-1_16 |isbn=978-3-319-12537-4 }}</ref>

Double-blind comparative studies found sertraline to have the same effect on panic disorder as [[paroxetine]] or [[imipramine]].<ref name="pmid21342080">{{cite journal |vauthors=Freire RC, Hallak JE, Crippa JA, Nardi AE |title=New treatment options for panic disorder: clinical trials from 2000 to 2010 |journal=Expert Opin Pharmacother |volume=12 |issue=9 |pages=1419–28 |date=June 2011 |pmid=21342080 |doi=10.1517/14656566.2011.562200 |s2cid=207479015 }}</ref> While imprecise, comparison of the results of trials of sertraline with separate trials of other anti-panic agents ([[clomipramine]], [[imipramine]], clonazepam, [[alprazolam]], and [[fluvoxamine]]) indicates approximate equivalence of these medications.<ref name="pmid10945134" />