Editing Reelin (section)

=== In adults ===
{{Further|Adult neurogenesis}}
In the adult nervous system, reelin plays an eminent role at the two most active neurogenesis sites, the subventricular zone and the dentate gyrus. In some species, the neuroblasts from the subventricular zone migrate in chains in the [[rostral migratory stream]] (RMS) to reach the olfactory bulb, where reelin dissociates them into individual cells that are able to migrate further individually. They change their mode of migration from tangential to radial, and begin using the radial glia fibers as their guides. There are studies showing that along the RMS itself the two receptors, [[ApoER2]] and [[VLDLR]], and their intracellular adapter [[DAB1]] function independently of Reelin,<ref name="pmid17494763" /> most likely by the influence of a newly proposed ligand, [[thrombospondin-1]].<ref name="pmid18946489" /> In the adult dentate gyrus, reelin provides guidance cues for new neurons that are constantly arriving to the granule cell layer from subgranular zone, keeping the layer compact.<ref name="dentate_gyrus" />

Reelin also plays an important role in the adult brain by modulating cortical pyramidal neuron [[dendritic spine]] expression density, the branching of [[dendrite]]s, and the expression of [[long-term potentiation]]<ref name="LTP2" /> as its secretion is continued diffusely by the GABAergic cortical interneurons those origin is traced to the medial [[ganglionic eminence]].

In the adult organism the non-neural expression is much less widespread, but goes up sharply when some organs are injured.<ref name="Kobold_2002_liver1" /><ref name="pmid17120005" /> The exact function of reelin upregulation following an injury is still being researched.{{citation needed|date=January 2016}}