Editing Phenothiazine (section)

=== As an anthelminthic ===

It was introduced as anthelminthic in livestock in 1940 and is considered, with [[thiabendazole]], to be the first modern anthelminthic.<ref name=Nielsen>{{cite journal | last1 = Nielsen | first1 = MK | display-authors = etal | date = Jul 2014 | title = Anthelmintic resistance in equine parasites--current evidence and knowledge gaps | journal = Vet Parasitol | volume = 204 | issue = 1–2| pages = 55–63 | pmid = 24433852 | doi = 10.1016/j.vetpar.2013.11.030}}</ref> The first instances of resistance were noted in 1961.<ref name=Nielsen/> Among anthelmintics, Blizzard et al. 1990 found only [[paraherquamide]] to have similar activity to phenothiazine. It is possible that they share the same [[mode of action]].<ref name="Monaghan-Tkacz-1990">{{cite journal | last1=Monaghan | first1=Richard L. | last2=Tkacz | first2=Jan S. | title=Bioactive Microbial Products: Focus upon Mechanism of Action | journal=[[Annual Review of Microbiology]] | publisher=[[Annual Reviews (publisher)|Annual Reviews]] | volume=44 | issue=1 | year=1990 | issn=0066-4227 | doi=10.1146/annurev.mi.44.100190.001415 | pages=271–331| pmid=2252385 }}</ref> Uses for this purpose in the US are still described<ref>The Texas A&M University System; Texas AgriLife Extension Service [http://animalscience.tamu.edu/wp-content/uploads/sites/14/2012/04/dairy-integrated-pest-mgmt.pdf Integrated pest management of flies in Texas dairies] {{Webarchive|url=https://web.archive.org/web/20140811054151/http://animalscience.tamu.edu/wp-content/uploads/sites/14/2012/04/dairy-integrated-pest-mgmt.pdf |date=2014-08-11 }}</ref> but it has "virtually disappeared from the market."<ref>Heinz Mehlhorn, Philip M. Armstrong.  Encyclopedic Reference of Parasitology: Diseases, Treatment, Therapy, Volume 2. Springer Science & Business Media, 2001 {{ISBN|9783540668299}}</ref>{{rp|369}}

In the 1940s it also was introduced as antihelminthic for humans; since it was often given to children, the drug was often sold in chocolate, leading to the popular name, "worm chocolate." Phenothiazine was superseded by other drugs in the 1950s.<ref name=DDD/>