Editing Pediatrics (section)

=== Metabolism ===
Drug metabolism primarily occurs via enzymes in the liver and can vary according to which specific enzymes are affected in a specific stage of development.<ref name=":1" /> Phase I and Phase II enzymes have different rates of maturation and development, depending on their specific mechanism of action (i.e. [[oxidation]], [[hydrolysis]], [[acetylation]], [[methylation]], etc.). Enzyme capacity, [[Clearance (pharmacology)|clearance]], and [[half-life]] are all factors that contribute to metabolism differences between children and adults.<ref name=":1" /><ref name=":2">{{Cite journal |last1=Batchelor |first1=Hannah Katharine |last2=Marriott |first2=John Francis |date=2015 |title=Paediatric pharmacokinetics: key considerations |journal=British Journal of Clinical Pharmacology |volume=79 |issue=3 |pages=395–404 |doi=10.1111/bcp.12267 |issn=1365-2125 |pmc=4345950 |pmid=25855821}}</ref> Drug metabolism can even differ within the pediatric population, separating neonates and infants from young children.<ref name=":0" />