Editing Paracetamol (section)

====Dental and other post-surgical pain====
Pain after a dental surgery provides a reliable model for the action of analgesics on other kinds of acute pain.<ref name="pmid32027199">{{cite journal |vauthors=Pergolizzi JV, Magnusson P, LeQuang JA, Gharibo C, Varrassi G |title=The pharmacological management of dental pain |journal=Expert Opin Pharmacother |volume=21 |issue=5 |pages=591–601 |date=April 2020 |pmid=32027199 |doi=10.1080/14656566.2020.1718651 |s2cid=211046298}}</ref> For the relief of such pain, paracetamol is inferior to ibuprofen.<ref name= "pmid24338830">{{cite journal |vauthors=Bailey E, Worthington HV, van Wijk A, Yates JM, Coulthard P, Afzal Z |title=Ibuprofen and/or paracetamol (acetaminophen) for pain relief after surgical removal of lower wisdom teeth |journal=Cochrane Database Syst Rev |volume= |issue=12 |pages=CD004624 |date=December 2013 |pmid=24338830 |doi= 10.1002/14651858.CD004624.pub2|pmc=11561150 }}</ref> Full therapeutic doses of nonsteroidal anti-inflammatory drugs (NSAIDs) ibuprofen, [[naproxen]] or [[diclofenac]] are clearly more efficacious than the paracetamol/codeine combination which is frequently prescribed for dental pain.<ref name="pmid32286125">{{cite journal |vauthors=Hersh EV, Moore PA, Grosser T, Polomano RC, Farrar JT, Saraghi M, Juska SA, Mitchell CH, Theken KN |title=Nonsteroidal Anti-Inflammatory Drugs and Opioids in Postsurgical Dental Pain |journal=J Dent Res |volume=99 |issue=7 |pages=777–786 |date=July 2020 |pmid=32286125 |doi=10.1177/0022034520914254 |pmc=7313348 }}</ref> The combinations of paracetamol and NSAIDs ibuprofen or diclofenac are promising, possibly offering better pain control than either paracetamol or the NSAID alone.<ref name="pmid24338830"/><ref name="pmid23904576">{{cite journal |vauthors=Moore PA, Hersh EV |title=Combining ibuprofen and acetaminophen for acute pain management after third-molar extractions: translating clinical research to dental practice |journal=J Am Dent Assoc |volume=144 |issue=8 |pages=898–908 |date=August 2013 |pmid=23904576 |doi=10.14219/jada.archive.2013.0207}}</ref><ref name="pmid23794268">{{cite journal |vauthors=Derry CJ, Derry S, Moore RA |title=Single dose oral ibuprofen plus paracetamol (acetaminophen) for acute postoperative pain |journal=Cochrane Database Syst Rev |volume= 2019|issue=6 |pages=CD010210 |date=June 2013 |pmid=23794268 |pmc=6485825 |doi=10.1002/14651858.CD010210.pub2}}</ref><ref name="pmid30245281">{{cite journal |vauthors=Daniels SE, Atkinson HC, Stanescu I, Frampton C |title=Analgesic Efficacy of an Acetaminophen/Ibuprofen Fixed-dose Combination in Moderate to Severe Postoperative Dental Pain: A Randomized, Double-blind, Parallel-group, Placebo-controlled Trial |journal=Clin Ther |volume=40 |issue=10 |pages=1765–1776.e5 |date=October 2018 |pmid=30245281 |doi=10.1016/j.clinthera.2018.08.019 |doi-access=free |title-link = doi }}</ref> Additionally, the paracetamol/ibuprofen combination may be superior to paracetamol/codeine and ibuprofen/codeine combinations.<ref name="pmid23904576"/>

A meta-analysis of general post-surgical pain, which included dental and other surgery, showed the paracetamol/codeine combination to be more effective than paracetamol alone: it provided significant pain relief to as much as 53% of the participants, while the placebo helped only 7%.<ref name="pmid19160199">{{cite journal |vauthors= Toms L, Derry S, Moore RA, McQuay HJ |title=Single dose oral paracetamol (acetaminophen) with codeine for postoperative pain in adults |journal=Cochrane Database Syst Rev |volume= 2009|issue=1 |pages=CD001547 |date=January 2009 |pmid=19160199 |pmc=4171965 |doi=10.1002/14651858.CD001547.pub2}}</ref>